The effect of trifluoperazine on muscle tension and cytoplasmic Ca2+ level in guinea pig ileum.
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概要
- 論文の詳細を見る
In guinea pig ileal muscle strips, trifluoperazine (TFP) inhibited the high K<SUP>+</SUP>-induced contraction with an IC50 of 1.9 μM and the Ca<SUP>2+</SUP>-induced contraction in skinned fiber with an IC50 of 44 μM. TFP decreased the high K<SUP>+</SUP>-induced increase in cytoplasmic Ca<SUP>2+</SUP> level at the concentration 3 μM, which did not inhibit the contraction in skinned fiber. It is suggested that the inhibitory effect of TFP on the high K<SUP>+</SUP>-induced contraction is mainly due to the decrease in cytoplasmic Ca<SUP>2+</SUP>.
- 公益社団法人 日本薬理学会の論文
著者
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Hori Masatoshi
Department Of Radiology Graduate School Of Medicine Osaka University
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Shimizu Kazumasa
Department Of Medicine Monash Medical Centre
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URAKAWA Norimoto
Department of Veterinaly Pharmacology, Faculty of Agriculture, University of Tokyo
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NAKAJYO Shinjiro
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical Colleg
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