EFFECTS OF OUABAIN ON HIGH-K INDUCED CONTRACTIONS OF VARIOUS SMOOTH MUSCLE TISSUES IN THE GUINEA-PIG
スポンサーリンク
概要
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The effects of ouabain on contraction, cellular Na concentration, and <SUP>45</SUP>Ca uptake of various smooth muscle tissues depolarized by high-K (62.7 mM) solution were studied. In the taenia coil and ileum isolated from guinea-pig, ouabain (2×10<SUP>-6</SUP>M 5×10<SUP>-5</SUP>M) increased cellular Na concentration and strongly inhibited K-contraction. A good correlation between cellular Na concentration and inhibition of tension was obtained both in the taenia coil and ileum. In the portal vein, aorta, and uterus, ouabain failed to induce relaxation and slightly increased the cellular Na. A long-time exposure to ouabain (1×10<SUP>-3</SUP>M) attenuated the response to high-K in the portal vein and uterus but not in the aorta. The inhibitory effect of ouabain in the taenia coil and ileum was antagonized by an increase in external Ca, and the inhibition was accompanied by a decrease in cellular <SUP>45</SUP>Ca content. A possibility exists that excess cellular Na inhibits K-induced Ca influx, although there is a tissue-specific difference. The data also suggest that the inhibitory effect of Na-accumulation is dissimilar to that of verapamil with respect to the tissue-specific difference.
- 社団法人 日本薬理学会の論文
著者
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KISHIMOTO Tadashi
Department of Urology, Nihon University School of Medicine
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URAKAWA Norimoto
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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Kishimoto Tadashi
Department Of Genetic Resources Ii National Institute Of Agrobiological Resources Kan' Nondai T
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URAKAWA Norimoto
Department of Veterinaly Pharmacology, Faculty of Agriculture, University of Tokyo
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KISHIMOTO Tadashi
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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