ARTIFICIAL BUFFERS DO NOT INHIBIT CONTRACTILE RESPONSES IN THE SMOOTH MUSCLE OF RAT PORTAL VEIN AND GUINEA PIG TAENIA COLI
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概要
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Effects of substitution for NaHCO<SUB>3</SUB> (and 5% CO<SUB>2</SUB>) in the physiological solution with equimolar N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid (HEPES) or morpholinopropane sulfonic acid (MOPS) (and 100% O<SUB>2</SUB>) at various pH levels on the contractility of smooth muscle were examined. At pH 7.4, spontaneous contraction in rat portal vein was not inhibited by the artificial buffer solutions, as compared to findings in the case of bicarbonate buffer solution. Norepinephrine-dose response curve in the case of rat portal vein and the histamine-dose response curve in cases of guinea pig taenia coli remained unchanged in the artificial buffer solutions. At pH 7.2 and 7.0, the spontaneous contraction in portal vein was reversibly inhibited either in artificial or in bicarbonate buffer solutions. The norepinephrine and histamine-dose response curves shifted downwards and/or to the right in these low pH solutions. Thus, HEPES and MOPS had no inhibitory effect on the smooth muscle contractility. Since low pH strongly inhibited the contractility, attention should be directed to the temperature-dependent decreases in pKa of the artificial buffers (i.e., if pH of the solution is adjusted at room temperature and then warmed, pH decreases).
- 社団法人 日本薬理学会の論文
著者
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Karaki Hideaki
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Suzuki Tadahiko
Department Of Surgery Osaka City University Medical School
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URAKAWA Norimoto
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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URAKAWA Norimoto
Department of Veterinaly Pharmacology, Faculty of Agriculture, University of Tokyo
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Karaki Hideaki
Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo
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