Calcium Channel Blocker-Like Action of Reserpine in Smooth Muscle.
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概要
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The effect of reserpine on vascular and intestinal smooth muscles was examined. In these muscles, reserpine inhibited the high K<SUP>+</SUP>-induced contraction, and this inhibitory effect was antagonized by the increase in external Ca<SUP>2+</SUP> concentration and also by a Ca<SUP>2+</SUP> channel activator, Bay k8644. In rabbit aorta, increases in cytosolic Ca<SUP>2+</SUP> level and muscle tension due to high K<SUP>+</SUP> were inhibited in parallel by reserpine. These results suggest that reserpine inhibits L-type Ca<SUP>2+</SUP> channels to inhibit smooth muscle contraction.
- 公益社団法人 日本薬理学会の論文
著者
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Moriyama Takahiro
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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Satoh Takumi
Department Of Chemistry College Of Science And Engineering Aoyama Gakuin University
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Karaki Hideaki
Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo
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Moriyama Takahiro
Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo
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Kuriki Hiroyuki
Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo
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SATOH Takumi
Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo
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