Calcium Channel Blocker-Like Action of 1,9-Dideoxyforskolin in Vascular Smooth Muscle.
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory effect of 1, 9-dideoxyforskolin (DFK) on the contraction of rat aorta was compared with that of forskolin. DFK inhibited the contraction induced by high K<SUP>+</SUP> more strongly than that induced by norepinephrine, whereas forskolin more strongly inhibited the norepinephrine-induced contraction. The inhibitory effect of DFK on high K<SUP>+</SUP>-induced contraction was antagonized by an increase in extracellular Ca<SUP>2+</SUP> concentration. DFK inhibited the increase in cytosolic Ca<SUP>2+</SUP> level and contraction in parallel whereas forskolin inhibited the contraction more strongly than the cytosolic Ca<SUP>2+</SUP> level. These results suggest that DFK, but not forskolin, inhibits vascular smooth muscle contraction by a Ca<SUP>2+</SUP> channel blocker-like action.
- 公益社団法人 日本薬理学会の論文
著者
-
Karaki Hideaki
Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo
-
Abe Asaki
Division of Animal Science, Faculty of Agriculture, Okayama University
関連論文
- D-Galactosamine Induced Hepatocyte Apoptosis is Inhabited in vivo and in Cell Culture by a Calcium Calmodulin Antagonist, Chlorpromazine, and a Calcium Channel Blocker, Verapamil
- Antihypertensive Effects of Peptides in Autolysate of Bonito Bowels on Spontaneously Hypertensive Rats
- Mechanism of Human Urotensin II-Induced Contraction in Rat Aorta
- Difference in Signal Transduction Mechanisms Involved in 5-Hydroxytryptamine- and U46619-Induced Vasoconstrictions
- Ca^-Sensitization of Contraction in the h1 Calponin-Deficient Smooth Muscle
- O-37 Inhibition of Contraction by Chronic Treatment with Anticancer Drug Doxorubicin in Organ Culture.(Proceedings of the 27th Annual Meeting)
- Inhibition of High K^+ -Induced Contraction by the ROCKs Inhibitor Y-27632 in Vascular Smooth Muscle : Possible Involvement of ROCKs in a Signal Transduction Pathway
- Actin-Depolymerizing Effect of Dimeric Macrolides, Bistheonellide A and Swinholide A^1
- Novel Actin Depolymerizing Macrolide Aplyronine A
- Cellu8lar Changes of Rat Embryonic Fibroblasts by an Actin-Polymerization Inhibitor, Bistheonellide A, from a Marine Sponge
- Effects of a Prostaglandin I_2 Analog Iloprost on Cytoplasmic Ca^ Levels and Muscle Contraction in Isolated Guinea Pig Aorta
- The Inhibitory Effect of Li^+ on Contractile Elements of Intestinal Smooth Muscle
- B-19 Cell damage induced by a phosphatase inhibitor.
- Changes in smooth muscle contraction in colitis model of rat induced by trinitrobenzenesulfonic acid (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- The mechanism of alterations in contractile properties of intestinal smooth muscle in TNBS-treated rat.(GENERAL SESSION BY POSTER PRESENTATION)(LIVER AND DIGESTIVE SYSTEM)
- Contribution of Chloride Channel Activation to the Elevated Muscular Tone of the Pulmonary Artery in Monocrotaline-Induced Pulmonary Hypertensive Rats
- Species- and Temperature-Dependency of the Decrease in Myofilament Ca^ Sensitivity Induced by β-Adrenergic Stimulation
- Proteolysis of Acidic Calponin by μ-Calpain
- Cicletanine-Induced Decreases in Cytosolic Ca^ Level and Contraction in Vascular Smooth Muscle
- Effects of Chronic Oral Administration of Isosorbide Dinitrate on In Vitro Contractility of Rat Arterial Smooth Muscle
- HYPEROSMOTIC APPLICATIONS OF KCI INDUCE VASCULAR SMOOTH MUSCLE CONTRACTION WHICH IS INDEPENDENT OF EXTERNAL Ca
- Ca2+-Dependent and Independent Mechanisms of Sustained Contraction in Vascular Smooth Muscle of Rat Aorta
- Carbachol but Not Acetylcholine Inhibits Contraction by the Protein Kinase C-Dependent and -Independent Pathways in the Smooth Muscle of Guinea Pig Taenia Caeci
- ARTIFICIAL BUFFERS DO NOT INHIBIT CONTRACTILE RESPONSES IN THE SMOOTH MUSCLE OF RAT PORTAL VEIN AND GUINEA PIG TAENIA COLI
- CHANGES IN TISSUE WEIGHT AND CALCIUM CONTENT IN VARIOUS HIGH POTASSIUM SOLUTIONS IN SMOOTH MUSCLE OF GUINEA PIG TAENIA COLI
- EFFECTS OF PALYTOXIN ON MECHANICAL AND ELECTRICAL ACTIVITIES OF GUINEA PIG PAPILLARY MUSCLE
- EFFECTS OF PALYTOXIN ON ISOLATED INTESTINAL AND VASCULAR SMOOTH MUSCLES
- Effect of Phorbol Esters on Cytosolic Ca^ Level, Myosin Phosphorylation and Muscle Tension in High K^+ : Stimulated Bovine Tracheal Smooth Muscle
- EFFECT OF HISTAMINE ON CALCIUM MOVEMENT IN GUINEA PIG TAENIA COLI
- A SHIFT OF CELLULAR CALCIUM TO A MORE SLOWLY EXCHANGEABLE FRACTION DURING CONTRACTION IN GUINEA PIG TAENIA COLI
- High K+,Na+-deficient solution inhibits tension,O2 consumption,and ATP synthesis in smooth muscle.
- INCREASE IN 85Sr UPTAKE BY ELEVATED CONCENTRATION OF K IN GUINEA PIG TAENIA COLI
- Potassium-induced contraction in smooth muscle.
- Calcium Channel Blocker-Like Action of Reserpine in Smooth Muscle.
- Role of endothelium in the contractions induced by norepinephrine and clonidine in rat aorta.
- Increase in membrane permeability in the absence of Ca and Mg in the smooth muscle of guinea-pig taenia coli.
- Inhibitory effects of forskolin on vascular smooth muscle of rabbit aorta.
- Method for simultaneous determination of creatine phosphate and adenine nucleotides in the intestinal smooth muscle of guinea-pig taenia caeci using high-performance liquid chromatography.
- Contractile effects of jellyfish toxin extracted from Carybdea rastonii on isolated rabbit aorta.
- Simultaneous recordings of calcium signals and mechanical activity using fluorescent dye fura 2 in isolated strips of vascular smooth muscle.
- Isoproterenol Changes the Relationship between Cytosolic Ca2+ and Contraction in Guinea Pig Taenia Caecum.
- Release of prostaglandins during the contraction of rat aorta induced by ouabain and K+-free solution.
- Leakage of the fluorescent Ca2+ indicator fura-2 in smooth muscle.
- High K-induced contractions in rabbit and monkey tracheal smooth muscle.
- Different effects of verapamil on cytosolic Ca2+ and contraction in norepinephrine-stimulated vascular smooth muscle.
- Dibutyryl Cyclic AMP and Forskolin Inhibit Phosphatidylinositol Hydrolysis, Ca2+ Influx and Contraction in Vascular Smooth Muscle.
- Endothelin dissociates muscle tension from cytosolic Ca2+ in vascular smpoth muscle of rat carotid artery.
- Calcium Channel Blocker-Like Action of 1,9-Dideoxyforskolin in Vascular Smooth Muscle.
- Verapamil-sensitive and less sensitive contractions in the intestinal smooth muscle of the guinea-pig taenia caeci.