Dibutyryl Cyclic AMP and Forskolin Inhibit Phosphatidylinositol Hydrolysis, Ca2+ Influx and Contraction in Vascular Smooth Muscle.
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概要
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Dibutyryl cyclic AMP and forskolin inhibited the contraction induced by norepinephrine (NE) more strongly than the high K<SUP>+</SUP>-induced contraction in isolated rat aorta. These inhibitors inhibited the <SUP>45</SUP>Ca<SUP>2+</SUP> influx stimulated by NE but not that by high K<SUP>+</SUP>, and they inhibited NE-induced inositol monophosphate accumulation. These results suggest that cAMP inhibits NE-induced contraction, at least partly, by inhibiting the α-adrenoceptor-mediated signal transduction and high K<SUP>+</SUP>-induced contraction by decreasing Ca<SUP>2+</SUP> sensitivity but not Ca<SUP>2+</SUP> influx.
- 公益社団法人 日本薬理学会の論文
著者
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Kang Seung
Department Of Analytical Research Service International Scientific Standards Ltd. A Battelle Company
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Ahn Hee
Department Of Chemistry And Center For Electro- And Photo-responsive Molecules Korea University
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Chang Ki
Department Of Agricultural Chemistry College Of Agriculture Chungnam National University
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Karaki Hideaki
Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo
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Kang Seung
Department of Biochemistry, College of Pharmacy, Joongang University
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Chang Ki
Department of Pharmacology, College of Medicine, Gyeongsang National University
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