Ca<SUP>2+</SUP>-Dependent and Independent Mechanisms of Sustained Contraction in Vascular Smooth Muscle of Rat Aorta
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概要
- 論文の詳細を見る
Norepinephrine (NE), prostaglandin F<SUB>2α</SUB> (PG), 12-deoxyphorbol 13-isobutyrate (DPB) and high K<SUP>+</SUP> induced sustained increase in cytosolic Ca<SUP>2+</SUP> ([Ca<SUP>2+</SUP>]<SUB>i</SUB>) and muscle tension in rat aorta. Verapamil, at the concentration which abolished the high K<SUP>+</SUP>-induced changes, also abolished the increase in [Ca<SUP>2+</SUP>]<SUB>i</SUB> due to NE, PG and DPB although contractions were only partially inhibited. Excess EGTA further decreased [Ca<SUP>2+</SUP>]<SUB>i</SUB> although a part of the contraction was not inhibited. These results indicate that the sustained contractions induced by NE, PG and DPB are due to increase in [Ca<SUP>2+</SUP>]<SUB>i</SUB>, increase in Ca<SUP>2+</SUP> sensitivity of contractile elements, and a Ca<SUP>2+</SUP>-independent mechanism.
著者
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Ozaki Hiroshi
Department Of Electronic Engineering Faculty Of Engineering Osaka University
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Sato Koichi
Department Of Artificial Organs National Cardiovascular Center Research Institute
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Ohyama Tatsuya
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Karaki Hideaki
Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo
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