Endothelin dissociates muscle tension from cytosolic Ca2+ in vascular smpoth muscle of rat carotid artery.
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概要
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Endothelin induced rapid increase followed by a decrease in cytosolic Ca<SUP>2+</SUP> ([Ca<SUP>2+</SUP>]i) and a slow increase in muscle tension in the vascular smooth muscle strip of rat carotid artery. Thus, the endothelin-induced contraction was smaller, and it, became gradually greater than high K-induced contraction at a given [Ca<SUP>2+</SUP>], i. In Ca<SUP>2+</SUP>-free solution, endothelin induced a transient increase in [Ca<SUP>2+</SUP>]i and a sustained contraction. These results suggest that endothelin-induced contraption is due to the increase in [Ca<SUP>2+</SUP>]i, the time-dependent change in Ca<SUP>2+</SUP>-sensitivity of contractile elements, and the mechanism which is independent of the increment in [Ca<SUP>2+</SUP>]i.
- 公益社団法人 日本薬理学会の論文
著者
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Sakata Kiyoshi
Department Of Electrical Engineering Hiroshima University
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Ozaki Hiroshi
Department Of Electronic Engineering Faculty Of Engineering Osaka University
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Sato Koichi
Department Of Artificial Organs National Cardiovascular Center Research Institute
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Karaki Hideaki
Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo
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