Mechanism of abnormal intestinal motility in inflammatory bowel disease : how smooth muscle contraction is reduced?
スポンサーリンク
概要
- 論文の詳細を見る
Intestinal inflammation alters the contractile activity of intestinal smooth muscle. Motility disorders of the gastrointestinal tract are clinically important symptoms, because they are often associated with severe interstitial inflammation. In addition, the motility disorders secondarily induce abnormal growth of the intestinal flora, and the resulting disturbance of this flora aggravates the pathogenesis of mucosal inflammation. This in turn aggravates the intestinal dysmotility; i.e., it is an inflammatory spiral. Therefore, it is important to elucidate the mechanisms involved in the changes in motor function which occur in intestinal inflammation. Recent studies have revealed several molecular mechanisms responsible for the decreased motility which occurs in an inflamed gastrointestinal tract. In the present review, we discuss the functional failure of smooth muscle cells, including changes in the activity of muscarinic receptors, ion channels and the endogenous myosin phosphatase inhibitor CPI-17.
- 日本平滑筋学会の論文
著者
-
Hori Masatoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University
-
Ozaki Hiroshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University
-
Hori Masatoshi
Department Of Radiology Graduate School Of Medicine Osaka University
-
Hori M
Leaf Tobacco Research Center Japan Tobacco Inc.:(present Address)laboratory Of Insect Science And Bi
-
Ozaki H
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences University Of
-
Ozaki Hiroshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit
-
OHAMA TAKASHI
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The Univers
-
Hori M
Division Of Veterinary Pharmacology Nippon Veterinary And Animal Science University
-
Hori Masatoshi
Division Of Veterinary Pharmacology Nippon Veterinary And Animal Science University
-
Ozaki Hiroshi
Department Of Electronic Engineering Faculty Of Engineering Osaka University
-
Ozaki Hiroshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
-
OHAMA Takashi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
関連論文
- A novel automatic liver surface registration method using spherical harmonics (パターン認識・メディア理解)
- A novel automatic liver surface registration method using spherical harmonics (画像工学)
- A novel automatic liver surface registration method using spherical harmonics (医用画像)
- Time-Dependent Phenotypic and Contractile Changes of Pulmonary Artery in Chronic Hypoxia–Induced Pulmonary Hypertension
- Segmentation of liver in low-contrast images using K-means clustering and a priori knowledge (パターン認識・メディア理解)
- Segmentation of liver in low-contrast images using K-means clustering and a priori knowledge (画像工学)
- Segmentation of liver in low-contrast images using K-means clustering and a priori knowledge (医用画像)
- A rule based technique for liver segmentation in CT data (医用画像)
- Automated Determination of the Liver Boundary in CT Data Based on Anatomical Knowledge and Level Set Method
- Large-Scale Analysis of Chlorophyll Fluorescence Kinetics in Synechocystis sp. PCC 6803 : Identification of the Factors Involved in the Modulation of Photosystem Stoichiometry
- Angiographic evaluation of hepatic arterial damage after transarterial chemoembolization for hepatocellular carcinoma
- Hypervascular hepatocellular carcinoma : Combined dynamic MDCT and SPIO-enhanced MRI versus combined CTHA and CTAP
- Isotropic Diffusion-weighted MR Imaging with Tetrahedral Gradients in the Upper Abdomen
- Evaluation of renal arteries in living renal donors : comparison between MDCT angiography and gadolinium-enhanced 3D MR angiography
- Principles and techniques of transcatheter embolotherapy for peripheral vascular lesions
- Antioxidant, Free Radical-Scavenging, and NF-κB-Inhibitory Activities of Phytosteryl Ferulates : Structure-Activity Studies
- Antioxidant, Free Radical–Scavenging, and NF-κB–inhibitory Activities of Phytosteryl Ferulates: Structure–Activity Studies
- Downregulation of CPI-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients
- Prospective Respiratory-triggered Multidetector Row CT (MDCT) for Abdominal Examinations : Initial Experience with a Prototype
- Efficacy of Multi-slice Helical CT Venography for the Diagnosis of Deep Venous Thrombosis : Comparison with Venous Sonography
- Enhancement of MMP-9 Activity in THP-1 Cells by 7-ketocholesterol and Its Suppression by the HMG-CoA Reductase Inhibitor Fluvastatin
- Mechanism of Human Urotensin II-Induced Contraction in Rat Aorta
- Difference in Signal Transduction Mechanisms Involved in 5-Hydroxytryptamine- and U46619-Induced Vasoconstrictions
- Ca^-Sensitization of Contraction in the h1 Calponin-Deficient Smooth Muscle
- O-37 Inhibition of Contraction by Chronic Treatment with Anticancer Drug Doxorubicin in Organ Culture.(Proceedings of the 27th Annual Meeting)
- 21B-11-1 Toxicity of anticancer drug doxorubicin on organ cultured vascular tissue.
- Inhibition of High K^+ -Induced Contraction by the ROCKs Inhibitor Y-27632 in Vascular Smooth Muscle : Possible Involvement of ROCKs in a Signal Transduction Pathway
- Repellency of essential oils against the cigarette beetle, Lasioderma serricorne (Fabricius)(Coleoptera: Anobiidae)
- Actin-Depolymerizing Effect of Dimeric Macrolides, Bistheonellide A and Swinholide A^1
- Novel Actin Depolymerizing Macrolide Aplyronine A
- Cellu8lar Changes of Rat Embryonic Fibroblasts by an Actin-Polymerization Inhibitor, Bistheonellide A, from a Marine Sponge
- The Influence of Chronic Sympathectomy on Cutaneous Blood Flow in the Rat Tail
- Effects of a Prostaglandin I_2 Analog Iloprost on Cytoplasmic Ca^ Levels and Muscle Contraction in Isolated Guinea Pig Aorta
- Intestinal Gene Expression in TNBS Treated Mice Using GeneChip and Subtractive cDNA Analysis : Implications for Crohn's Disease(Molecular and Cell Biology)
- The 5-HT_4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage
- Inhibitory Mechanism of Papaverine on Carbachol-Induced Contraction in Bovine Trachea
- The Inhibitory Effect of Li^+ on Contractile Elements of Intestinal Smooth Muscle
- B-19 Cell damage induced by a phosphatase inhibitor.
- A17 OKADAIC ACID AND CALYCULIN A, TOXINS ISOLATED FROM MARINE SPONGE, INHIBIT PROTEIN PHOSPHATASE ACTIVITY AND CONTRACT SMOOTH MUSCLE
- Effects of Trypsin on Cytosolic Calcium Levels in Rat Aortic Endothelium
- Effect of discodermin A, an antimiclobial peptide, on the cytoplasm membrane
- Carbachol Induces Ca^-Dependent Contraction via Muscarinic M_2 and M_3 Receptors in Rat Intestinal Subepithelial Myofibroblasts
- Time-Dependent Phenotypic and Contractile Changes of Pulmonary Artery in Chronic Hypoxia-Induced Pulmonary Hypertension
- Mechanism of abnormal intestinal motility in inflammatory bowel disease : how smooth muscle contraction is reduced?
- Changes in smooth muscle contraction in colitis model of rat induced by trinitrobenzenesulfonic acid (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- The mechanism of alterations in contractile properties of intestinal smooth muscle in TNBS-treated rat.(GENERAL SESSION BY POSTER PRESENTATION)(LIVER AND DIGESTIVE SYSTEM)
- Contribution of Chloride Channel Activation to the Elevated Muscular Tone of the Pulmonary Artery in Monocrotaline-Induced Pulmonary Hypertensive Rats
- Species- and Temperature-Dependency of the Decrease in Myofilament Ca^ Sensitivity Induced by β-Adrenergic Stimulation
- Macrophages in Muscle Layer of Gastrointestinal Tract : Impairment of Muscle Contraction by Treatment with Lipopolysaccharide
- Proteolysis of Acidic Calponin by μ-Calpain
- Relaxant Effect of Prostaglandin D2–Receptor DP Agonist on Liver Myofibroblast Contraction
- Calcineurin Contributes to the Enhancing Effect of Adenosine on Nerve Growth Factor-Induced Neurite Outgrowth via the Decreased Duration of p38 Mitogen-Activated Protein Kinase Phosphorylation
- Halichlorine Reduces Monocyte Adhesion to Endothelium Through the Suppression of Nuclear Factor-κB Activation
- Isolation and Characterization of Bovine Intestinal Subepithelial Myofibroblasts
- Carbachol Induces Ca2+-Dependent Contraction via Muscarinic M2 and M3 Receptors in Rat Intestinal Subepithelial Myofibroblasts
- Cicletanine-Induced Decreases in Cytosolic Ca^ Level and Contraction in Vascular Smooth Muscle
- Effects of Chronic Oral Administration of Isosorbide Dinitrate on In Vitro Contractility of Rat Arterial Smooth Muscle
- Ca2+-Dependent and Independent Mechanisms of Sustained Contraction in Vascular Smooth Muscle of Rat Aorta
- 17β-Estradiol Induces Gastrointestinal Motility Disorder by Decreasing CPI-17 Phosphorylation Via Changes in Rho-Family G-Protein Rnd Expression in Small Intestine
- An Algorithm for Generating All The Directed Paths and Its Application
- Isolation and Characterization of Bovine Intestinal Subepithelial Myofibroblasts
- Repellency of shiso oil components against the cigarette beetle, Lasioderma serricorne(Fabricius)(Coleoptera: Anobiidae)
- Functional Magnetic Resonance Imaging of Auditory Cortex: with Special Reference to the Side of Aural Stimulation
- Effect of Phorbol Esters on Cytosolic Ca^ Level, Myosin Phosphorylation and Muscle Tension in High K^+ : Stimulated Bovine Tracheal Smooth Muscle
- Increased Inhibitory Effect of Phorbol Ester on Cytosolic Ca2+ Level and Contraction in Rat Myometrium after Gestation
- ON THE INHIBITORY MECHANISM OF BASSIANOLIDE, A CYCLODEPSIPEPTIDE, IN ACETYLCHOLINE-INDUCED CONTRACTION IN GUINEA-PIG TAENIA COLI
- DUAL ACTIONS OF VANADATE ON HIGH K-INDUCED CONTRACTION IN GUINEA-PIG TAENIA COLI
- Some Results on Syntheses of Sorting Networks Based on the Two-dimensional Arrangement of Signal Lines
- THE MECHANISM OF CONTRACTILE ACTION OF PALYTOXIN ON VASCULAR SMOOTH MUSCLE OF GUINEA-PIG AORTA
- Organ Culture as a Useful Method for Studying the Biology of Blood Vessels and Other Smooth Muscle Tissues
- ^F-FDG PET/MRI fusion in characterizing pancreatic tumors : comparison to PET/CT
- Relaxant Effect of Prostaglandin D_2-Receptor DP Agonist on Liver Myofibroblast Contraction
- Halichlorine Reduces Monocyte Adhesion to Endothelium Through the Suppression of Nuclear Factor-κB Activation
- Effect of Mosapride on Prednisolone-Induced Gastric Mucosal Injury and Gastric-Emptying Disorder in Dog
- Ovarian Masses : MR Imaging with T_1-weighted 3-dimensional Gradient-echo IDEAL Water-fat Separation Sequence at 3T
- Inhibitory Effect of Forskolin on Myosin Phosphorylation-Dependent and Independent Contractions in Bovine Tracheal Smooth Muscle.
- Segmentation of Liver in Low-Contrast Images Using K-Means Clustering and Geodesic Active Contour Algorithms
- Cytochalasin D Inhibits Smooth Muscle Contraction by Directly Inhibiting Contractile Apparatus.
- Contractile effects of jellyfish toxin extracted from Carybdea rastonii on isolated rabbit aorta.
- Simultaneous recordings of calcium signals and mechanical activity using fluorescent dye fura 2 in isolated strips of vascular smooth muscle.
- Effects of palytoxin on Na, K and ATP contents of vascular smooth muscle of rabbit aorta.
- A comparative study of the contraction induced by high K/Na deficient solution in the trachea, gall bladder and urinary bladder in guinea-pig.
- Prostaglandin D2 Inhibits Collagen Secretion From Lung Fibroblasts by Activating the DP Receptor
- Isoproterenol Changes the Relationship between Cytosolic Ca2+ and Contraction in Guinea Pig Taenia Caecum.
- The effect of trifluoperazine on muscle tension and cytoplasmic Ca2+ level in guinea pig ileum.
- Species differences in inhibitory effect of Li+ on high K+-induced contraction in the lleal longitudinal smooth muscle.
- Phagocytotic Activation of Muscularis Resident Macrophages Inhibits Smooth Muscle Contraction in Rat Ileum
- Different effects of verapamil on cytosolic Ca2+ and contraction in norepinephrine-stimulated vascular smooth muscle.
- Endothelin dissociates muscle tension from cytosolic Ca2+ in vascular smpoth muscle of rat carotid artery.
- IL-17A Induces Hypo-contraction of Intestinal Smooth Muscle via Induction of iNOS in Muscularis Macrophages
- Prostaglandin D_2 Inhibits Collagen Secretion From Lung Fibroblasts by Activating the DP Receptor