Simultaneous recordings of calcium signals and mechanical activity using fluorescent dye fura 2 in isolated strips of vascular smooth muscle.
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概要
- 論文の詳細を見る
In rat aortic strips loaded with a Ca<SUP>2+</SUP> indicator, fura 2, the Ca<SUP>2+</SUP> signal and contractile tension were simultaneously recorded. On the addition of high K<SUP>+</SUP> or noradrenaline, the 500 nm fluorescence produced by excitation at 340 nm increased and that produced by excitation at 380 nm decreased. EGTA decreased the 340 nm fluorescence and increased the 380 nm fluorescence in resting and stimulated muscles. Tension changes were always preceded by fluorescent changes.
- 公益社団法人 日本薬理学会の論文
著者
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Satoh Takumi
Department Of Chemistry College Of Science And Engineering Aoyama Gakuin University
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Ozaki Hiroshi
Department Of Electronic Engineering Faculty Of Engineering Osaka University
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Sato Koichi
Department Of Artificial Organs National Cardiovascular Center Research Institute
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Karaki Hideaki
Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo
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