ON THE INHIBITORY MECHANISM OF BASSIANOLIDE, A CYCLODEPSIPEPTIDE, IN ACETYLCHOLINE-INDUCED CONTRACTION IN GUINEA-PIG TAENIA COLI
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概要
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The effect of bassianolide (BASS), a cyclodepsipeptide, was investigated on mechanical response, membrane potential, intracellular Na and K contents and <SUP>45</SUP>Ca uptake in response to acetylcholine (ACh) in guinea-pig taenia coli. BASS (10<SUP>-5</SUP> M) as well as verapamil (5×10<SUP>-7</SUP> M) and papaverine (3×10<SUP>-5</SUP> M) selectively inhibited the tonic component of the contraction induced by ACh (10<SUP>-5</SUP> M), but scarcely affected the phasic one. In contrast, atropine (3×10<SUP>-8</SUP> M) inhibited both components of contraction. BASS did not modify the change in membrane potential by ACh. BASS, ACh and the combination of both did not influence the intracellular Na and K contents and the <SUP>45</SUP>Ca uptake. These data show that BASS seems unlikely to have the property of an ionophore. BASS slightly inhibited both the tonic and phasic components of contraction induced by 60 mM K in a non-selective manner, though verapamil and papaverine inhibited the tonic component more potently than the phasic one. Verapamil decreased the increased <SUP>45</SUP>Ca uptake in the muscle soaked in 60 mM K medium, but BASS did not. Since BASS selectively inhibits the tonic component of the ACh-induced contraction, the inhibitory mechanism of BASS seems to be different from that of verapamil, papaverine or atropine; and the mechanism may be beyond the interactions with a binding activity of ACh to the muscarinic receptor, membrane potential and the contractile machinery of the intestinal smooth muscle.
- 社団法人 日本薬理学会の論文
著者
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Ozaki Hiroshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit
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Suzuki Akinori
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Shimizu Kazumasa
Department Of Medicine Monash Medical Centre
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URAKAWA Norimoto
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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Nakajyo Shinjiro
Laboratory Of Veterinary Pharmacology Department Of Veterinary Medicine Veterinary And Life Science
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NAKAJYO Shinjiro
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College
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KOMETANI Atsuko
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College
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Ozaki Hiroshi
Department Of Electronic Engineering Faculty Of Engineering Osaka University
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URAKAWA Norimoto
Department of Veterinaly Pharmacology, Faculty of Agriculture, University of Tokyo
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OZAKI Hiroshi
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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Suzuki Akinori
Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo
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NAKAJYO Shinjiro
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical Colleg
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