Isoproterenol Changes the Relationship between Cytosolic Ca2+ and Contraction in Guinea Pig Taenia Caecum.
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概要
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To determine the role of β-adrenoceptors in the regulation of intestinal smooth muscle, the action of isoproterenol (ISO)on cytoplasmic Ca<SUP>2+</SUP> level ([Ca<SUP>2+</SUP>]<SUB>cyt</SUB>)and mechanical activity in the isolated guinea pig taenia caecum was examined. Spontaneous changes in [Ca<SUP>2+</SUP>]cyt and contraction were inhibited by ISO (0.1-1μM)without changing resting [Ca<SUP>2+</SUP>]<SUB>cyt</SUB>. ISO more strongly inhibited the histamine-induced contraction than the high K<SUP>+</SUP> -induced contraction. ISO inhibited muscle tension more strongly than [Ca<SUP>2+</SUP>]<SUB>cyt</SUB> stimulated by high K<SUP>+</SUP> and thus shifted the [Ca<SUP>2+</SUP>]<SUB>cyt</SUB> -tension curve to the lower-right. In the muscle stimulated by histamine, on the other hand, ISO inhibited both [Ca<SUP>2+</SUP>]<SUB>cyt</SUB> and tension. Salbutamol, aβ<SUB>2</SUB>-selective agonist, showed similar effects as ISO on spontaneous, high K<SUP>+</SUP> and histamine-stimulated [Ca<SUP>2+</SUP>]<SUB>cyt</SUB> and tension. Stimulation of β-adrenoceptors by ISO increased cyclic AMP content without changing cyclic GMP content. These results suggest that activation of β<SUB>2</SUB>-adrenoceptors by ISO inhibits the contractions by two mechanisms of action: decrease in Ca<SUP>2+</SUP> sensitivity of contractile elements in the muscle stimulated by K<SUP>+</SUP> -depolarization and decrease in [Ca<SUP>2+</SUP>]<SUB>cyt</SUB> in the muscle stimulated by histamine. These effects may be mediated by cyclic AMP.
- 公益社団法人 日本薬理学会の論文
著者
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Hori Masatoshi
Department Of Radiology Graduate School Of Medicine Osaka University
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Ozaki Hiroshi
Department Of Electronic Engineering Faculty Of Engineering Osaka University
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Karaki Hideaki
Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo
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Kwon Seong-Chung
Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo
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Hori Masatoshi
Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo
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