Macrophages in Muscle Layer of Gastrointestinal Tract : Impairment of Muscle Contraction by Treatment with Lipopolysaccharide
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概要
- 論文の詳細を見る
The morphology and function of resident macrophages in the muscle layer and in the subserosa of the gastrointestinal tract are described. FITC-dextran injected via the tail vein of a mouse or rat demonstrated a regular arrangement of macrophages on a whole mount preparation of the muscle layer. Electron microscopy revealed inactive phagocytosis under normal conditions. After a 4-8 hr incubation of ratileal muscle with lipopoly-saccharide(LPS) to investigate its effect on muscle contraction, macrophages began to express inducible nitric oxide synthase(iNOS) and released nitric oxide. This macrophage response was accompanied by the expression of cyclooxygenase-2(COX-2) immunoreactivity and the production of prostaglandins. The muscarinic agonist-induced contraction was greatly inhibited by LPS treatment, and this inhibition was reversed by either iNOS or COX-2 inhibitors. We concluded that one of the functions of muscular macrophages wss the modulation of smooth muscle contraction under pathological conditions. The mechanism of iNOS upregulation indicated by our experiment is discussed.
- 日本組織細胞化学会の論文
著者
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Hori Masatoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University
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Ozaki Hiroshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University
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Hori Masatoshi
Department Of Radiology Graduate School Of Medicine Osaka University
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Hori M
Leaf Tobacco Research Center Japan Tobacco Inc.:(present Address)laboratory Of Insect Science And Bi
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TORIHASHI Shigeko
Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
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Ozaki H
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences University Of
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Ozaki Hiroshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit
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Hori M
Division Of Veterinary Pharmacology Nippon Veterinary And Animal Science University
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Hori Masatoshi
Division Of Veterinary Pharmacology Nippon Veterinary And Animal Science University
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Ozaki Hiroshi
Department Of Electronic Engineering Faculty Of Engineering Osaka University
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Torihashi S
Nagoya Univ. Graduate School Of Medicine Nagoya Jpn
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Torihashi Shigeko
Department Of Anatomy & Cell Biology Nagoya University Graduate School Of Medicine
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鳥橋 茂子
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
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Ozaki Hiroshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
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