Inhibitory Effects of KW-3902, a Selective Adenosine A1-Receptor Antagonist, on the Adenosine-Induced Shortening of Action Potential Duration in Guinea Pig Atrial Muscles.
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概要
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We investigated the effects of KW-3902 (8-(noradamantan-3-yl)-1, 3-dipropylxanthine), a newly-synthesized selective adenosine A<SUB>1</SUB>-receptor antagonist, on the shortening of action potential duration (APD) in guinea pig atria exposed to adenosine. The APD shortening by adenosine was inhibited by KW-3902 at higher than 10<SUP>-8</SUP> M, but not by 10<SUP>-5</SUP> M of KF17837, an adenosine A<SUB>2</SUB>-receptor antagonist. These results support the notion that the APD shortening by adenosine in atria is mediated via adenosine A<SUB>1</SUB>-receptors. The potency of KW-3902 in antagonizing the APD-shortening were similar to those in antagonizing the negative inotropic and chronotropic action of adenosine in the isolated right atria, suggesting that these responses to adenosine are mediated via the receptors of the same type.
- 公益社団法人 日本薬理学会の論文
著者
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Moriyama Takahiro
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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KARASAWA Akira
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Karasawa Akira
Deparment Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Mori Tatsuya
Department Of Advanced Bioscience Faculty Of Agriculture Kinki University
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Moriyama Takahiro
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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