Protective Effect of Cisapride against Indomethacin-Induced Obstruction of the Gastric Mucosal Hemodynamics in Rats.
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概要
- 論文の詳細を見る
We investigated the effect of cisapride, a gastroprokinetic agent, on the obstructed gastric mucosal hemodynamics induced by indomethacin using an organ reflectance spectrophotometry system in rats. Indomethacin (10 mg/kg, i.v.) reduced both the gastric mucosal blood volume and the gastric mucosal blood oxygenation. Pretreatment with cisapride (0.1 mg/kg, i.v.) prevented these deteriorations. The presently-clarified gastric mucosal protective effect of cisapride may contribute to its therapeutic efficacy.
- 公益社団法人 日本薬理学会の論文
著者
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Sato Nobuhiro
Department Of Critical Care Medicine Iwate Medical University
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Kitazawa Takio
Department Of Biosciences School Of Veterinary Medicine Rakuno Gakuen University
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Ogihara Tatsuo
Department Of Gastroenterology Juntendo University School Of Medicine
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YOKOYAMA Toshihide
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Karasawa Akira
Deparment Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Ishii Akio
Department Of Mechanical Science And Bioengineering Graduate School Of Engineering Science Osaka University
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Kitazawa Takio
Department of Veterinary Pharmacology, Facultyof Dairy Science, Rakuno Gakuen University
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Sato Nobuhiro
Department of Cardio-angiology, Kitasato University School of Medicine
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