Protective Effects of KW-3902, a Novel Adenosine Al-Receptor Antagonist, against Gentamicin-Induced Acute Renal Failure in Rats.
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概要
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We investigated the possible renal protective effects of KW-3902 (8-(noradamantan-3-yl)-1, 3-dipropylxanthine), an adenosine A<SUB>1</SUB>-receptor antagonist, against gentamicin (GM)-induced acute renal failure (ARF) in rats. ARF was induced by subcutaneous injection of GM at 80 mg/kg/day for 12 days. KW-3902 (0.001-0.1 mg/kg, p.o., twice daily) attenuated the increases of serum creatinine and urea nitrogen and the decrease of creatinine clearance in rats treated with GM. In contrast, furosemide and trichlormethiazide aggravated the GM-induced nephrotoxicity. These results suggest that KW-3902 can ameliorate the GM-induced ARF and that endogenous adenosine may be involved in GM-induced ARF via the adenosine A<SUB>1</SUB>-receptor.
- 公益社団法人 日本薬理学会の論文
著者
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Yao Kozo
Department Of Pharmacology And Molecular Biology Pharmaceutical Research Center Kyowa Hakko Kogyo Co
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Karasawa Akira
Deparment Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Sato Kiyoshi
Department Of Biological And Chemical Engineering Gunma University
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Kusaka Hideaki
Department of Pharmacology and Department of Toxicology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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