Early Thrombolysis by Recombinant Tissue-Plasminogen Activator Is Beneficial to the Ischemic Myocardium
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概要
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We examined the effect of coronary thrombolysis by recombinant tissue-plasminogen activator (rtPA) on infarct size using a thrombin-induced thrombosis model of open-chest anesthetized dog. Occlusive thrombus was induced by injection of thrombin (100 U) in the left anterior descending coronary artery (LAD). The intravenous infusion of rtPA (10 μg/kg/min) was started at 30 min (30 min-ischemia group) or at 60 min (60 min-ischemia group) after the formation of thrombus, and was continued for 30 min. Spontaneous thrombolysis was not observed in the 360 min-ischemia (vehicletreated) group. Intravenous infusion of rtPA elicited thrombolysis within 30 min in all the dogs except in one in the 60 min-ischemia group. The infarct size was significantly reduced by rtPA-induced thrombolysis. The shorter the duration of the ischemia, the loger the effect of the drug, and the infarct size after thrombolysis was smaller in the 30 min-ischemia group than in the 60 min-ischemia group. Ischemia-induced changes in ST-segment of electrocardiogram (ECG) were significantly ameliorated after thrombolysis in both 60 min-and 30 min-ischemia group. These results suggest that early reperfusion of coronary thrombosis by rtPA is beneficial to the ischemic myocardium.
- 公益社団法人日本薬学会の論文
著者
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KARASAWA Akira
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Karasawa Akira
協和醗酵工業
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Karasawa A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Laboratory Of Plant Pathology Department Of Applied Life Science Graduate School Of Agricultural Sci
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Karasawa Akira
Department Of Bioscience Faculty Of Science And Technology Kwansei Gakuin University
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Kubo K
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Kubo Kazuhiro
Pharmaceutical Research Laboratories Of Kyowa Hakko Kogyo Co. Ltd.
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Kubo Kazuhiro
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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HIGO Katsuya
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Higo K
Kyowa Hakko Kogyo Co. Ltd. Shizuoka Jpn
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Karasawa Akira
Deparment Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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KUBO Kazuhiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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KUBO Kazuhiro
Department of Cardiovascular Pharmacology, Pharmaceuticals Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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