Effects of Olopatadine Hydrochloride on the Increase of Histamine and Peptide-Leukotrienes Concentrations in Nasal Lavage Fluid Following the Antigen-Antibody Reaction in Actively Sensitized Guinea Pigs
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the mechanism for the amelioration by olopatadine hydrochloride (olopatadine) of allergic rhinitis, we determined its effects on the increase of chemical mediator concentrations in nasal lavage fluid following the intranasal antigen challenge in guinea pigs actively sensitized with DNP-Ascaris. The concentrations of histamine and peptide-leukotrienes increased 10 min after the challenge. Olopatadine at 10 mg/kg (p.o.) significantly prevented the increase of histamine and tended to inhibit the increase of peptide-leukotrienes. The inhibition by olopatadine of the nasal symptoms seems to involve the inhibitory effect on the releases of histamine and, possibly, p-LTs into the nasal cavity.
- 社団法人 日本薬理学会の論文
- 2001-04-01
著者
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石井 昭男
協和発酵医薬研
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KARASAWA Akira
Drug Department Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd
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ISHII Akio
Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Karasawa Akira
協和醗酵工業
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Karasawa A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Laboratory Of Plant Pathology Department Of Applied Life Science Graduate School Of Agricultural Sci
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ISHII Akio
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Lt
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MIYAKE Kiyomi
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co. Ltd
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HORIKOSHI Kaori
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Kogyo Co., Ltd.
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Miyake K
Kyowa Hakko Kogyo Co. Ltd. Tokyo Jpn
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Horikoshi Kaori
協和醗酵工業
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Horikoshi K
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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ISHII AKIO
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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Horikoshi Kaori
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Miyake Kiyomi
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd
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Ishii A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Ikeda Yoshimi
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd
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Hayashi Ken-ichi
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Kobayashi H
Department Of Earth & Spece Science Graduate School Of Science Osaka University
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Karasawa Akira
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Drug Department Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Kobayashi H
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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石井 昭男
協和発酵工業(株)医薬研究所
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ISHII Akio
Toxicological Research Laboratories Kyowa Hakko Kogyo Co., Ltd.
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Horikoshi Kaori
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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