新抗てんかん薬Sodium Dipropylacetateの研究 代謝物と代謝過程の検討
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概要
- 論文の詳細を見る
The metabolites and metabolic pathway of a new anticonvulsant drug, sodium dipropylacetate (DPA), in rat were investigated using ^<14>C-labelled DPA. Most of the metabolites in urine and bile was glucronide and free DPA was as little as one-seventh of the total metabolites. In feces, only free DPA was detected, and the possibility of enterohepatic circulation of DPA was presumed. A part of dosed DPA was excreted in expired air in the form of CO_2. This degradative reaction took place in liver mitochondria and required CoA and oxygen. It was stimulated by ATP and EDTA, and inhibited by various enzymic reaction inhibitors such as malonate, Antimycin-A, chloropromazine, PCMB, and 2,4-dinitrophenol. Therefore, this degradation is not a one-step reaction, decarboxylation, but must be β-oxidation of a fatty acid.
- 社団法人日本薬学会の論文
- 1972-07-25
著者
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出口 隆志
協和発酵工業株式会社医薬研究所
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高平 汎志
協和醗酵工業株式会社富士研究室
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石井 昭男
協和発酵工業株式会社医薬研究所
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九木野 和暁
協和酸酵工業株式会社富士工場研究室
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峯浦 和幸
協和酸酵工業株式会社富士工場研究室
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出口 隆志
協和酸酵工業株式会社富士工場研究室
-
石井 昭男
協和酸酵工業株式会社富士工場研究室
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高平 汎志
協和酸酵工業株式会社富士工場研究室
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ISHII Akio
Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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峯浦 和幸
協和発酵工業株式会社医薬研究所
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