N-アセチルグルタミン-アルミニウム錯体化合物(KW-110)の生化学的研究(第2報)ラットでの胃液分泌機能に対するKW-110の効果について

概要

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Effect of oral administration of KW-110 on gastric juice components was examined in Shay rats. Following an oral administration of KW-110,the volume of gastric juice was not changed but the pH of gastric juice was increased. Further, protein contents and peptic activity in gastric juice were lowered, while aluminum content in the stomach wall was raised. The binding of aluminum to the stomach wall occurred selectively in the glandular portion. The kinds of protein decreased in gastric juice after the oral admini-stration of KW-110 was found to be nonspecific judging from the molecular distribution in the experiments with Sephadex G-75 gel filtration. Aluminum in orally administered KW-110 might be bound to protein secreted in the glandular stomach. These results were emphasized by the polyacrylamide gel electrophoresis of aluminum-protein complexes ; the electrophoretic pattern of protein in normal gastric juice was consistent with that of protein which was dissociated from aluminum-protein complexes and dissolved in artificial gastric juice (pH 1.2).
公益社団法人日本薬学会の論文
1974-05-25