N-アセチルグルタミン-アルミニウム錯体化合物(KW-110)の生化学的研究(第1報)^<14>C-KW-110のラットでの生体内運命について

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The metabolic fate of ^<14>C-KW-110 in rats has been studied. After oral administration of 500 mg/kg of ^<14>C-KW-110 to rats, the radioactivity excreted was 73.3% in expiratory CO_2,16.4% in feces, and 8.2% in urine, whereas aluminum it KW-110 was excreted in feces only. After the oral administration of KW-110 to rats, the radioactivity was distributed in all tissues in rats and especially high i0n stomach, intestinal tracts, liver, and kidney, but aluminum in KW-110 administered was distributed only in digestive tracts, and retained in stomach for about 5-7 hr after its oral administration and gradually moved into intestinal tracts. N-Acetylglutamine, glutamine, -and urea were identified as urinary radioactive metabolites after the oral administration of KW-110 and they accounted for 46.5%, 24.7%, and 27.4%, respectively, of total radioactivity excreted in 48-hr urine. The radioactive substances detected in serum were also N-acetylglutamine, glutamine, and glutamic acid.
社団法人日本薬学会の論文
1974-05-25