フラビン存在下におけるピリドキシン-5'-りん酸およびピリドキシン-4',5'-環状りん酸エステルの光酸化について (ピリドキサール・りん酸の生産に関する研究-1,2-)

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It was found that both pyridoxine-5'-phosphate (PIN-P) and pyridoxine-4', 5'-cyclic-phosphate (cyclicPlN-P) were decomposed by the irradiation with visible light in the presence of flavin compounds, such as riboflavin, FAD and FMN (coenzyme of PIN-P oxidase). The some conditions and the mechanism of photochemical decomposition of PIN-P were studied. The results were as follows: (1) PIN-P and cyclicPlN-P were decomposed by the irradiation with visible light in the presence of catalytic amount of flavin compounds under the aerobic condition. (2) The photosensitizing activities of flavin compounds were in the order of FMN=FR>FAD. (3) The optimal pH of this reaction was 7_??_8. (4) This reaction was inhibited with metal ions such as Cu2+, Hg2+, Fe2+, Co2+, Mn2+, Pb2+, Al2+ and Ni2+. (5) The stability of FMN during irradiation was increased with PIN-P. (6) In the optimal condition, both PIN-P and cyclicPlN-P were oxidized to 4'-pyridoxic acid-5'-phosphate through PAL-P. 4'-Pyridoxic acid-5'-phosphate was thought to be futher decomposed.
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