クロラムフエニコール親水性高分子化合物共沈物の溶解性と消化管吸収

概要

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Physicochemical properties of coprecipitate of chloramphenicol (CP)-polyvinylpyrrolidone (PVP) and CP-hydroxypropylcellulose (HPC) were investigated. The dissolution rate and apparent solubility of CP from the coprecipitate increased in the CP-PVP system, but the increase of apparent solubility was not significant in CP-HPC system. IR spectral changes due to the possible formation of hydrogen bonds were observed in the coprecipitate of CP-PVP system, but not in that of CP-HPC system. The CP in the coprecipitate was found to be an amorphous form by the differential scanning calorimetry and X-ray diffraction measurement. In CP-PVP system, difference in properties between the coprecipitate and physical mixture was always found when the mixing ratio (w/w) of CP : PVP was less than 7 : 3. The absorption of CP after oral administration of the coprecipitate powder and pellet in the dog was 1.2-1.9 times greater in area under plasma level-time curve (0-9 hr) than that of the mixture.
社団法人日本薬学会の論文
1978-08-25