Thiamine Derivatives of Disulfide Type. XIV. Kinetic Studies on the Reaction between Thiamine and Propyl Propane-Thiolsulfinate or -Thiolsulfonate

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概要

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• Kinetic studies were conducted on the reaction between thiamine and propyl propane-thiolsulfinate (PrSSOPr) or -thiolsulfonate (PrSSO_2Pr) to give thiamine propyl disulfide (B_1SSPr). The folllowing mechanisms were suggested for the reaction with PrSSOPr. [chemical formula] (1) B_1SH+PrSSOPr→^^<k_5>B_1SSPr+(PrSOH) (2) [chemical formula] (3) The reaction with PrSSO_2Pr was more complicated, since the hydrolysis of PrSSO_2Pr was not neglected, as shown in the following equations. B_1SH+PrSSO_2Pr→^^<k_3>B_1SSPr+PrSO_2H (4) PrSSO_2Pr+H_2O→^^<k_4>(PrSOH)+PrSO_2H (5) The rate of conversion to thiol-type thiamine was found to be the rate limiting step and k_1 determined as 1.66×10^<-4> sec^<-1> at pH 8 and 37°. The validity of the discussion was supported by the agreement between the experimental data and the simulation curves by analog computation.

• 公益社団法人日本薬学会の論文
• 1971-12-25

著者

• 長谷川 淳

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 花野 学

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 野上 寿

  東京大学薬学部

• 野上 寿

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 花野 学

  College Of Pharmacy Nihon University

• 花野 学

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 青木 勝夫

  Technological Research Laboratories, Research and Development Division, Takeda Chemical Industries,

• 野上 寿

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 青木 勝夫

  Pharmacy Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 青木 勝夫

  Pharmacy Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.

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