Studies on Decomposition and Stabilization of Drugs in Solution. XVIII. The Hydrolysis of Phthalylsulfathiazole
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概要
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The hydrolysis of phthalylsulfathiazole at 60° was studied. The pH-rate profile was similar to that of phthalamic acid in acidic region, and rate constant of intramolecular reaction was 1.12×10^<-3> sec^<-1>. In strong alkaline region the rate was proportional to hydroxide ion concentration and the rate constant was 3.80×10^<-6> liter・mole^<-1> sec^<-1>. Reaction species were discussed in relation to observed rate constants and the rate expression was presented. ΔH^≐̸ was 18.1 kcal/mole and ΔS^≐̸ was -17.9 e.u.
- 公益社団法人日本薬学会の論文
- 1968-10-25
著者
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長谷川 淳
Faculty Of Pharmaceutical Sciences University Of Tokyo
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力久 忠昭
Faculty Of Pharmaceutical Sciences University Of Chiba
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野上 寿
Faculty of Pharmaceutical Sciences, University of Tokyo
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力久 忠昭
Faculty Of Pharmaceutical Sciences University Of Tokyo
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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松岡 徹
Faculty Of Pharmaceutical Sciences University Of Tokyo
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