Studies on Absorption and Excretion of Drugs. II. Kinetics of Penetration of Basic Drug, Aminopyrine, through the Intestinal Barrier in vitro.
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概要
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1) The intestinal absorption of aminopyrine as a representative of the basic drugs was investigated to prove the validity of equation (1) described previously. 2) From the three evidences, that is, a good fit of the data at pH 7.01 to equation (3), the statistical treatment of all the data, and the experiment at equilibrium state, it is concluded that aminopyrine penetrates the intestinal barrier with each specific coefficient, P_u and P_i, according to equation (1). 3) Respective values of the coefficients were statistically determined and the estimated value of P_u was 0.00266 (cc./cm./min.) and that of P_i 0.000242 (cc./cm./min.). From the ratio of P_u/P_i, it may be expected that aminopyrine is absorbed in its undissociated form according to Overton's hypothesis. 4) A fact that aminopyrine slowly penetrates the intestine is consistent with the result reported by Hogben, et al.
- 公益社団法人日本薬学会の論文
- 1962-11-25
著者
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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松沢 兌
Pharmaceutical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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松沢 兌
Faculty of Pharmaceutical Sciences, University of Tokyo
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