Studies on Powdered Preparations. XVIII. Dissolution Rate of Sulfadiazine in Various Aqueous Solutions.
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The following results were obtained on the dissolution of sulfadiazine in various aqueous solution. 1. On the dissolution in sucrose solution, with an increase of sucrose concentration, the saturated concentration, C_O was increased a little, and the dissolution constant, K_T, was decreased with an increase of viscosity following an increase of the concentration. The dissolution rate by practical representation, K_T×C_O, became smaller with an increase of sucrose concentration. The dissolution was in accordance with the Noyes-Nernst model, and C_O was coincident with the solubility, C_S.2. On the dissolution in sodium chloride solution, both K_T and C_O were decreased with an increase of the concentration of sodium chloride. The dissolution was in accordance with the Noyes-Nernst model.3. On the dissolution in sodium hydroxide solution, both K_T and C_O were increased with an increase of the concentration of sodium hydroxide. The dissolution was in accordance with the Nernst-Brunner model. The increase of K_T was considered to be due to the increase of diffusion coefficient of sodium hydroxide in the presence of sodium salt of sulfadiazine. 4. The dissolution in Na_2HPO_4 solution, in Mc'Ilvaine buffer solution and in hydrochloric acid solution were in accordance with the Higuchi model, and as an increase of concentration of the solution, C_O was increased by the change of hydrogen ion concentration. 5. The dissolution in urea solution did not fit to any of the model in Table I.
- 1966-04-25
著者
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永井 恒司
Faculty of Pharmaceutical Sciences, Hoshi University
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鈴木 章
Traditional Chinese Medicine Research Laboratory Kanebo Co. Ltd.
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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鈴木 章
Faculty of Pharmaceutical Sciences, University of Tokyo
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