Studies on Powdered Preparations. XIX. Dissolution Kinetics of Benzoic Acid Derivatives
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概要
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The dissolution rates of benzoic acid derivatives in water and in urea solution were measured by rotating disk method. The data of the dissolution in urea solution showed a good agreement qualitatively with the process in which there exist some reaction and the equilibrium is reached rather slowly in the diffusion layer and the solutes are transferred into the bulk solution under non-equilibrium state. That is, the dissolution rate constant, K_T, and the saturated concentration, C_O, showed the dependence on the lapse of time, and the initial dissolution rate constant, K_T(t→o), was almost the same as the value of K_T observed on the dissolution in water.
- 社団法人日本薬学会の論文
- 1966-04-25
著者
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永井 恒司
Faculty of Pharmaceutical Sciences, Hoshi University
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伊藤 孝治
Pharmaceutical Research Laboratory Research Laboratories Daiichi Seiyaku Co. Ltd.
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野上 寿
Faculty of Pharmaceutical Sciences, University of Tokyo
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伊藤 孝治
Research Laboratory of Pharmaceutics, Daiichi Seiyaku Co., Ltd.
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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