Binding of 1-Anilino-8-naphthalenesulfonate to Polyvinylpyrrolidone, Poly-N-vinyl-2-oxazolidone, Poly-N-vinyl-5-methyl-2-oxazolidone and Polyethylene Glycol-20M in Aqueous Solution
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概要
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The binding mechanism of 1-anilino-8-naphthalenesulfonate (ANS), called "hydrophobic probe, " to polyvinylpyrrolidone (PVP), poly-N-vinyl-2-oxazolidone (PVO), poly-N-vinyl-5-methyl-2-oxazolidone (PVMO) and polyethylene glycol-20M (PEG-20M) was investigated as an approach to understanding of the interaction between ANS and biological components. A high fluorescence emission was observed when the above synthetic water soluble polymers were added to aqueous solution of ANS. The emission maximum appeared at 480mμ by the excitation at 365mμ in the cases of PVP K-15,PVP K-30,PVO and PVMO, and at 475mμ in the case of PEG-20M. The fluorescence was polarized in ANS/PVP/water, as was described with Perrin's equation. The enhancement and the shift of fluorescence emission were not observed in ANS/polyethylene imine/water. The shift of signals to higher field on the proton magnetic resonance spectra of the model systems ANS/N-methyl-2-pyrrolidone/D_2O and ANS/N-chloroethyl-2-oxazolidone/D_2O suggested that ANS may stack on pyrrolidone and oxazolidone rings, respectively. PEG-20M gave a ultraviolet absorption spectrum and another infrared absorption around 1515cm^<-1> than PEG 4000 and 6000 did and also gave two peaks on the gel permeation chromatogram. The fluorescence intensity at 310mμ, excited at 265mμ, decreased with the increase of concentration of ANS. Accordingly, it was considered possible that some aromatic residue was incorporated in the PEG-20M molecule as have been reported in some other cases and this residue played an important role in the binding of ANS to PEG-20M.
- 公益社団法人日本薬学会の論文
- 1973-02-25
著者
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永井 恒司
Department of Pharmaceutics, Hoshi University
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永井 恒司
Faculty of Pharmaceutical Sciences, Hoshi University
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野上 寿
Faculty of Pharmaceutical Sciences, University of Tokyo
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河野 健治
Kyorin Chemical Laboratory
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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河野 健治
Faculty of Pharmaceutical Sciences, University of Tokyo
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