Sustained-Release Formulation of Buformin Hydrochloride

概要

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Using buformin hydrochloride, a highly water-soluble drug, as a model drug, a sustainedrelease dosage form was developed. Six granule formulations were prepared from corn starchlactose, synthetic aluminum silicate, ethyl cellulose, and polymethylmethacrylate, and five tablet formulations were prepared from corn starch-lactose, calcium hydrogen phosphate, crystalline cellulose, ethyl cellulose, and sodium polyacrylate. These formulations were subjected to dissolution tests for in vitro screening of potential retard forms. It was found that incorporation of sodium polyacrylate was very effective in reducing the release rate. Two formulations incorporating sodium polyacrylate were selected as the most successful retard forms in an in vitro study. They were orally administered to beagle dogs for in vivo evaluation. It was concluded that this material is one of the most promising excipients for a sustained-release dosage form which contains an extremely water-soluble drug.
公益社団法人日本薬学会の論文
1984-03-25