Effect of Compression Pressure and Formulation on the Available Surface Area of Flufenamic Acid in Tablets

概要

論文の詳細を見る
The effects of compression pressure and a disintegrant on the dissolution profile of flufenamic acid (FFA) in tablets were evaluated in relation to the time course of the available surface area (S(t)). The ratios of S(t) generated by time t to the total S(t) generated during the dissolution process (F(t)), which it was possible to obtain from dissolution tests on the tablets as well as on granules before compression, were well regreassed to the Weibull distribution and the log-normal distribution. The scale parameter (a) and the shape parameter (b) of the Weibull distribution increased as the compression pressure was increased, and also as the level of disintegrant was decreased. With regard to the regression to the log-normal distribution, the standard deviation (σ) of the S(t)-generated pattern increased as the compression pressure was increased, whereas it was unaffected by the level of disintegrant. By using the probability parameters thus obtained, the S(t)-generation patterns of FFA (200 mg) tablets at various compression pressures were simulated. When the compression pressure was low, and the disintegrant level was high, the patterns had a well-defined peak value, which was consistent with the disintegration time of the tablets.
公益社団法人日本薬学会の論文
1986-03-25