Enhancement of Dissolution Properties of Prednisolone from Ground Mixtures with Chitin or Chitosan
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概要
- 論文の詳細を見る
With a view to an application of chitin and chitosan to pharmaceutical preparations, the dissolution behavior of ground mixtures of prednisolone with chitin and chitosan was investigated. Ground mixtures of prednisolone with chitin and chitosan were prepared by cogrinding in a ball mill. The X-ray diffraction patterns and results of differential scanning calorimetry suggested that the size of crystals of prednisolone was decreased in the ground mixtures. The dissolution rate of prednisolone from the ground mixtures was significantly greater than that from the physical mixture or from intact prednisolone powder. These results indicate that chitin and chitosan can improve the dissolution properties of prednisolone.
- 公益社団法人日本薬学会の論文
- 1983-07-25
著者
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南部 直樹
Faculty Of Pharmaceutical Sciences Hoshi University
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永井 恒司
星薬科大学 薬剤
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永井 恒司
Faculty of Pharmaceutical Sciences, Hoshi University
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沢柳 洋市
Department Of Pharmacy University Of Sydney : Faculty Of Pharmaceutical Sciences Hoshi University
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沢柳 洋市
Faculty of Pharmaceutical Sciences, Hoshi University
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