Use of Chitosan for Sustained-release Preparations of Water-soluble Drugs
スポンサーリンク
概要
- 論文の詳細を見る
The applicability of chitosan as a vehicle for sustained-release preparations of water-soluble drugs was examined. Propranolol hydrochloride was selected as a model substance for this evaluation. Zero-order controlled release of propranolol hydrochloride from tablets containing chitosan was obtained in JP X disintegration medium No. 1 and in disintegration medium No. 2 following exposure to No. 1. Chitosan could be a useful vehicle for the controlled release of water-soluble drugs.
- 1982-11-25
著者
-
南部 直樹
Faculty Of Pharmaceutical Sciences Hoshi University
-
永井 恒司
Faculty of Pharmaceutical Sciences, Hoshi University
-
沢柳 洋市
Department Of Pharmacy University Of Sydney : Faculty Of Pharmaceutical Sciences Hoshi University
-
沢柳 洋市
Faculty of Pharmaceutical Sciences, Hoshi University
関連論文
- 第3回国際製剤学会議(3rd International Conference on Pharmaceutical Techonology)
- Synthesis and Properties of the Monoesters of 5-Fluorouridine with 4-Carboxybutyric Acid and Their Conjugates with Chitosan
- Evaluation of Bioavailability upon Oral Administration of Phytonadione Preparations in Beagle Dogs
- Pharmacokinetic Characteristics and Antitumor Activity of the N-Succinyl-chitosan-Mitomycin C Conjugate and the Carboxymethyl-chitin-Mitomycin C Conjugate
- Synthesis and Drug-Release Characteristics of the Conjugates of Mitomycin C with N-Succinyl-chitosan and Carboxymethyl-chitin
- In Vitro pH-Dependent Drug Release from N^4-(4-Carboxybutyryl)-1-β-D-arabinofuranosylcytosine and Its Conjugate with Poly-L-lysine or Decylenediamine-dextran T70
- Novel Preparation of Decylenediamine-dextran T70 and Inhibitory Activity toward Dihydrofolate Reductase of Decylenediamine-dextran T70-Methotrexate Conjugate(Pharmaceutical)
- Preparation of Dextran T70-Methotrexate Conjugate and Dextran T70-Mycophenolic Acid Conjugate, and in Vitro Effect of Dextran T70-Methotrexate on Dihydrofolate Reductase
- In Vitro Dissolution Profile and in Vivo Absorption Study of Sustained-Release Tablets Containing Chlorpheniramine Maleate with Water-Insoluble Glucan
- Sustained-Release Dosage Forms Containing Chlorpheniramine Maleate with Water-Insoluble Glucan
- Studies on Powdered Preparations. XIX. Dissolution Kinetics of Benzoic Acid Derivatives
- Mathematical Optimization of Formulation of Indomethacin/Polyvinylpolypyrrolidone : Methyl Cellulose Solid Dispersions by the Sequential Unconstrained Minimization Technique
- Stabilization of Amorphous State of Indomethacin by Solid Dispersion in Polyvinylpolypyrrolidone
- Directly Compressed Tablets of Acetaminophen using Several Binding Agents
- Dissolution Behavior of Flufenamic Acid dispersed in Cross-linked Insoluble Polyvinylpyrrolidone : Effect of Water-soluble Polymers added as the Third Component
- Adsorption of Benzoic Acid Derivatives by Carbon Black from Aqueous Solution and Related Phenomena
- Adsorption of Local Anesthetics from Aqueous Solution. Analysis of Factors Affecting the Nerve Blocking
- Particle Size Distribution Affects the Human Bioavailability of Phenytoin
- A New Method of Dissolution Testing for Oily Drug Preparations Using an Improved Apparatus
- A New Method for Dissolution Testing of Vitamin E Preparations in Test Medium Containing Sodium Glycochenodeoxycholate
- Enhancement of the Bioavailability of Cinnarizine from Its β-Cyclodextrin Complex on Oral Administration with L-Isoleucine as a Competing Agent
- Evaluation of Bioavailability upon Oral Administration of Cinnarizine-β-Cyclodextrin Inclusion Complex to Beagle Dogs
- Effect of β-Cyclodextrin on the Degradation Rate of Cinnarizine in Aqueous Solution
- Kinetics of Degradation of Cinnarizine in Aqueous Solution
- Dissolution and Bioavailability of Phenytoin in Phenytoin-Polyvinylpyrrolidone-Sodium Deoxycholate Coprecipitate
- Particle Size Dependency of Dissolution Rate and Human Bioavailability of Phenytoin in Powders and Phenytoin-Polyethylene Glycol Solid Dispersions
- Sustained-Release Formulation of Buformin Hydrochloride
- Model Barrier Affecting Drug Transport
- Disintegration of the Aspirin Tablets containing Potato Starch and Microcrystalline Cellulose in Various Concentrations
- Factors affecting the Adsorption of Chlorhexidine Gluconate by Hydroxyapatite
- Intranasal Administration of Human Fibroblast Interferon in Mice, Rats, Rabbits and Dogs
- Effect of Absorption Promoters in Intranasal Administration of Human Fibroblast Interferon as a Powder Dosage Form in Rabbits
- Enzyme Immunoassay of Human Fibroblast Interferon after Intranasal Administration with Several Excipients in Rabbits
- Dissolution Kinetics of Barbital Polymorphs
- Physico-chemical Approach to Biopharmaceutical Phenomena. I. Adsorption of Tryptophan from Aqueous Solution
- Dissolution Kinetics of Polyvinylpyrrolidone of Various Molecular Weights
- Dissolution Kinetics of Polyvinylpyrrolidone
- Rheological Studies on a Suspension of Water-Insoluble Glucan Produced by Streptococcus mutans(Pharmaceutical,Chemical)
- Directly Compressed Tablets containing Water-insoluble Glucan and Microcrystalline Cellulose in Addition to Lactose
- Adsorption of Phenothiazines from Aqueous Solution. Approach to Understanding of Membrane Action
- Dissolution of Thioridazine Hydrochloride from the Coprecipitate with Pectin
- Effect of β-Cyclodextrin on Sleeping Time Induced by Barbituric Acid Derivatives in Mice
- Specificity of Esterases and Structures of Prodrug Esters. III. Activity of Rat Tissue Homogenates, Rat Plasma and Porcine Liver Esterase for the Hydrolysis of 3', 5'-Bis-dicarboxylic Acid Hemiesters of 5-Fluoro-2'-deoxyuridine
- Specificity of Esterases and Structure of Prodrug Esters. II. Hydrolytic Regeneration Behavior of 5-Fluoro-2'-deoxyuridine (FUdR) from 3', 5'-Diesters of FUdR with Rat Tissue Homogenates and Plasma in Relation to Their Antitumor Activity
- Activity of Esterase in the Hydrolysis of 3', 5'-Diesters of 5-Fluoro-2'-deoxyuridine in Relation to the Structure of the Diester Prodrugs
- Optimum Formulation of Griseofulvin/Hydroxypropyl Cellulose Solid Dispersions with Desirable Dissolution Properties
- Factors Affecting the Dissolution of Griseofulvin Dispersed in Various Water-Soluble Polymers
- Dissolution Behavior of Chlorpropamide Polymorphs
- Highly Viscous Gel Ointment Containing Carbopol for Application to the Oral Mucosa
- Computer Optimization of Formulation of Flufenamic Acid/Polyvinylpolypyrrolidone/Methyl Cellulose Solid Dispersions
- Enhancement of Dissolution Properties of Prednisolone from Ground Mixtures with Chitin or Chitosan
- Dissolution Properties and Bioavailability of Phenytoin from Ground Mixtures with Chitin or Chitosan
- Dissolution of Diethazine Hydrochloride from the Coprecipitate with Pectin
- Development of a Tablet Excipient from Bagasse(Pharmaceutical)
- Kinetic Approach to Determine the Generation Rate of Available Surface Area during the Dissolution Process
- Effect of Compression Pressure and Formulation on the Available Surface Area of Flufenamic Acid in Tablets
- Influence of Wetting Factors on the Dissolution Behavior of Flufenamic Acid
- Dissolution Profiles of Nalidixic Acid Powders Having Weibull Particle Size Distribution
- Prediction of Available Surface Area of Powdered Particles of Flufenamic Acid in Tablets
- Kinetics of Hydrolysis of Oxazolam in Aqueous Solution
- Properties of Cyclodextrin Polymer as a Tabletting Aid
- Relationship between the Adsorption by Carbon Black from Aqueous Solution and the Biopharmaceutical Data of Sulfonamides
- Adsorption of Sulfonamides from Aqueous Solution
- Effects of Third Component on Hydrophobic and Hydrophilic Moities of Tryptophan in Aqueous Solution. Approach to Understanding of Denaturation of Globular Protein
- Effect of Third Component on Water Structure around Tryptophan in Aqueous Solution
- Solubility of Acetaminophen in Cosolvents
- Physico-chemical Approach to Biopharmaceutical Phenomena. V. Relationship between the Adsorption by Carbon Black from Aqueous Solution and the Biopharmaceutical Data of Barbituric Acid Derivatives
- Physico-chemical Approach to Biopharmaceutical Phenomena. IV. Adsorption of Barbituric Acid Derivatives by Carbon Black from Aqueous Solution
- Physico-chemical Approach to Biopharmaceutical Phenomena. III. Hydrophobic Bonding in the Adsorption of Tryptophan by Carbon Black from Aqueous Solution
- Physico-chemical Approach to Biopharmaceutical Phenomena. II. Hydrophobic Hydration of Tryptophan in Aqueous Solution
- Studies on Powdered Preparations. XIV. Wetting of Powder Bed and Disintegration Time of Tablet
- Factors Affecting Dissolution Rate of Cellulose Acetate Phthalate in Aqueous Solution
- Factors Affecting the Bioadhesive Property of Tablets Consisting of Hydroxypropyl Cellulose and Carboxyvinyl Polymer
- Interaction of Phenothiazines with Pectin in the Solid State
- Interaction of Phenothiazines with Pectin in Aqueous Solution
- Binding of 1-Anilino-8-naphthalenesulfonate to Polyvinylpyrrolidone, Poly-N-vinyl-2-oxazolidone, Poly-N-vinyl-5-methyl-2-oxazolidone and Polyethylene Glycol-20M in Aqueous Solution
- Mechanism of Adsorption of Phenols by Carbon Black from Aqueous Solution
- Molecular Sizes of Phenothiazines taken upon the Adsorption from Aqueous Solution and upon the Permeation through Cellulose Membrane
- Permeation of Phenothiazines through Cellulose Membrane
- Analysis of Solubility Properties of L-Tryptophan in Aqueous Solution based on the Effects of Third Component on Optical Rotatory Dispersion and on Adsorption by Carbon Black
- Complexation of Several Drugs with Water-Soluble Cyclodextrin Polymer(Pharmaceutical)
- Thermodynamic Properties of Polymorphs of Tolbutamide
- Permeation of Sulfonylureas through Cellulose and Dimethylpolysiloxane Membranes
- Disintegration and Dissolution Characteristics of Compressed Tablets Consisting of Hydroxypropyl Cellulose and Carboxyvinyl Polymer
- Dissolution Phenomena of Organic Medicinals involving Simultaneous Phase Changes
- Binding of 1-Anilinonaphthalene-8-sulfonate to Water Soluble Synthetic Polymers
- Enhancement of Dissolution Properties of Griseofulvin from Ground Mixtures with Chitin or Chitosan
- Directly Compressed Tablets containing Chitin or Chitosan in Addition to Mannitol
- Use of Chitosan for Sustained-release Preparations of Water-soluble Drugs
- Permeation of Drugs through Chitosan Membranes
- Directly Compressed Tablets containing Chitin or Chitosan in Addition to Lactose or Potato Starch
- Novel Computer Optimization Methodology for Pharmaceutical Formulations Investigated by Using Sustained-Release Granules of Indomethacin
- Ointment-type Oral Mucosal Dosage Form of Carbopol containing Prednisolone for Treatment of Aphtha
- Factors Affecting the Dissolution of Ketoprofen from Solid Dispersions in Various Water-soluble Polymers
- Mucosal Dosage Form of Lidocaine for Toothache using Hydroxypropyl Cellulose and Carbopol
- Factors affecting the Dissolution of Indomethacin dispersed in Various Water-Soluble Polymers
- 包接化合物の医薬への応用 (包接化合物)
- Analysis of Interfacial Transfer of Indomethacin following Dissolution of Indomethacin/Polyvinylpyrrolidone Coprecipitates
- Adsorption of Nicotinic and Isonicotinic Acid Derivatives by Hydroxyapatite from Aqueous Solutions
- 第9回アジア薬剤師会連合(FAPA)学術大会