Intranasal Administration of Human Fibroblast Interferon in Mice, Rats, Rabbits and Dogs

概要

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In previous studies on the nasal administration of human fibroblast interferon (HuIFN-β), only rabbits have been used. Therefore, this route was investigated in mice, rats, rabbits and dogs. HuIFN-β could be delivered across the nasal mucosa in mice, rats rabbits and dogs, when it was mixed with sodium glycocholate as an absorption promoter. However, the pattern of the plasma HulFN-β concentration-time curve was different from that in rabbits. Rabbits gave the highest value of the maximum plasma HuIFN-β concentration (C_<max>), but plasma HulFN-β declined rapidly thereafter, upon nasal administration of the powder dosage form (8.45 × 10^2 IU/g). In rats and dogs, C_<max> was lower than in rabbits, but plasma HulFN-βdeclined slowly after nasal administration of the powder or liquid dosage form (4-6 × 10^2 IU/g). These differences might be attributed to differences of absorption rate constant.
公益社団法人日本薬学会の論文
1990-02-25