A New Method of Dissolution Testing for Oily Drug Preparations Using an Improved Apparatus

概要

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A new method of dissolution testing for oily drug preparations, the drug and vehicles of which tend to float on the surface of the dissolution test medium, was investigated. In this study, a modified version of the paddle method of JPX, involving an additional (assistant) wing to stir the surface of the medium, was use. Moreover, polypropylene beads were added to the medium in order to enhance the efficiency of stirring. The 2nd fluid containing 20mM sodium glycochenodeoxycholate was used as a dissolution test medium. A linear relationship was observed between the percent of the drug dissolved and the lapse of time, and also between the dissolution rate and the number of beads used. It was found that there was an optimum rotation speed of the paddle.
公益社団法人日本薬学会の論文
1986-06-25