放出制御型薬物送達システム

概要

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With a view to finding an advanced technology of control of bioavailability, drug delivery systems have been investigated by controlled release, which are for (1) intrauterine, (2) buccal/gingival, (3) nasal, and (4) percutaneous administration. First the general concept of drug delivery systems by controlled release and then our results of trials are described. Among our trials, the productive ones are concerned with bioadhesive drug delivery systems and now their three commercial products are on the market, which have been developed on the basis of our investigations : (a) adhesive tablet of triamcinolone acetonide for aphthous stomatitis; (b) adhesive powder spray for extensive stomatitis; and (c) adhesive powder spray for nasal allergy. The others are : (d) a topical dosage form for carcinoma colli, which has been investigated in cooperation with gynecologists; (e) an oral mucosal dosage form for the absorption of insulin (f) a powder dosage form of nasal absorption of insulin; (g) a powder dosage form of nasal absorption of -interferone; (h) transdermal therapeutic systems of ionizable water-soluble drugs; (i) cyclohexane derivatives as percutaneous absorption enhancers.
公益社団法人日本薬学会の論文
1988-07-25