混合型ウイテプゾール基剤を用いたジクロフェナックナトリウム坐剤からの薬物放出性

概要

論文の詳細を見る
The mixed-type diclofenac sodium suppository consistsng of two kinds of hard fat (Witepsol W35, Witepsol E85) was prepared. The area under the drug release curve (ADT) increased and mean release time (MDT) decreased with the increase in the mixing ratio of Witepsol W35. When the drug release was examined at 36℃, the amount of drug released from the marketing suppository was only 9% of the mixed-type suppository which consisted of 50% Witepsol W35. A strength. surface morphology, thermal analysis parameters and penetration of methylene blue were measured as characteristics of mixed suppositories. The methylene blue penetrating ratio was measured by image analysis using a scanner and computer after the suppository was put into the methylene blue solution at 36℃. The fusion peak temperature and methylene blue penetrating ratio were strongly correlated with ADT and MDT values, while the strength and heat of fusion did not correlate well with these values. The penetrating ratio increased with the increase in the mixing ratio of Witepsol W35 in the suppository. While the suppository had retained its shape in the test fluid at 36℃, diclofenac sodium was fully released. The mixed-type suppository is therefor thought to be useful for patients with a low body temperature in order to eliminate their chronic pain.
日本医療薬学会の論文
1998-08-10