噴霧機構の異なる鼻腔内噴霧製剤の噴霧特性と服薬指導への適用 : アルデシンとアルデシン AQ ネーザル

概要

論文の詳細を見る
Beclomethasone dipropionate is a synthetic adrenal cortex hormone that is used in aerosols for the treatment of nasal-allergies. Recently. Aldecin AQ Nasal^<[O!R]> (AQ) has been put on the market as an alternative to Aldecin^<[O!R]> (AD) in which chlorofluorocarbon is used as the propellant. In this study. the spraying characteristics of AQ and AD were examined. The amount sprayed in one puff with AQ vemain constant from the 7 th to 110 th spray, while that with AD was remained constant from the first to 120 th spray. Therefore, a partient should be requested to spray the AQ at least 7 times prior to the first usage. When the patient spray AQ or AD 4 times a day in both nostrils, then AQ and AD can be for about 14 days and 15 days, respectively. After the spray tests using different lengths of cylinders and filter paper, a fractal analysis was performed on the sprayed morphology drawn on the filter paper. At a suitable distance from the nozzle of AQ the dispersed particles uniformly settled. The principal agent was concentrated on the nasal cavity near by the nostrils when the spray test was done by using a plastic nasal cavity model. This findings suggests that pharmacists must give properly advise patients on how to use AQ while breathing gently.
日本医療薬学会の論文
1996-12-10