Effect of β-Cyclodextrin on the Degradation Rate of Cinnarizine in Aqueous Solution
スポンサーリンク
概要
- 論文の詳細を見る
The degradation kinetics of cinnarizine in aqueous solution containing β-cyclodextrin at pH 1.20 and four different temperatures were investigated. The degradation of cinnarizine was found to be a pseudo first-order reaction. The pseudo first-order rate constant with β-cyclodextrin decreased with increase in the concentration of β-cyclodextrin at pH 1.20. From Arrhenius plots, the values of activation energy of the degradation in aqueous solution at pH 1.20 containing 3.26×10^<-3> and 15.32×10^<-3> M β-cyclodextrin were calculated to be 37.0 kcal/mol and 40.1 kcal/mol, respectively.
- 公益社団法人日本薬学会の論文
- 1985-05-25
著者
-
永井 恒司
星薬科大学 薬剤
-
町田 良治
Faculty of Pharmaceutical Sciences, Hoshi University
-
永井 恒司
Faculty of Pharmaceutical Sciences, Hoshi University
-
栢野 正則
Tokyo Research Laboratories, Eisai Co., Ltd.,
-
徳村 忠一
星薬科大学医療薬剤学教室
-
徳村 忠一
Research Laboratories of Technological Development, Eisai Co., Ltd.
-
栢野 正則
Research Laboratories of Technological Development, Eisai Co., Ltd.
-
立石 公男
Research Center of Technological Development, Eisai Co., Ltd.,
-
栢野 正則
Tokyo Research Laboratories Eisai Co. Ltd.
-
立石 公男
Research Laboratories Of Pharmaceutical Development Eisai Co. Ltd.
関連論文
- 薬剤師は科学者である : 科学を築いた薬剤師または薬局助手
- 医療法・薬剤師法の改正による薬剤師職能の変貌と薬学教育6年制
- グローバリゼーションと日本の薬学教育
- Drug Delivery System研究の現状と将来
- DDSを育てる環境
- DDS : 薬学/薬師ルネッサンス(DDS)
- 「経皮・経粘膜デリバリーの開発」への展望
- Drug Delivery System 研究の過去, 現在, 未来
- 12P-8-01 アジア薬剤師会連盟薬科大学 (FAPA・CP) による薬剤師卒後教育
- 南原利夫先生1996年FIP永年薬学研究顕著功績賞受賞
- Effects of Orally Administered Liposomes with Soybean-Derived Sterols and Their Glucosides on Rat Body Weight
- Effects of Dose, pH and Osmolarity on Intranasal Absorption of Recombinant Human Erythropoietin in Rats
- Synthesis and Properties of the Monoesters of 5-Fluorouridine with 4-Carboxybutyric Acid and Their Conjugates with Chitosan
- Evaluation of Liposomal Erythropoietin Prepared with Reverse-Phase Evaporation Vesicle Method by Subcutaneous Administration in Rats
- Evaluation of Bioavailability upon Oral Administration of Phytonadione Preparations in Beagle Dogs
- Pharmacokinetic Characteristics and Antitumor Activity of the N-Succinyl-chitosan-Mitomycin C Conjugate and the Carboxymethyl-chitin-Mitomycin C Conjugate
- Synthesis and Drug-Release Characteristics of the Conjugates of Mitomycin C with N-Succinyl-chitosan and Carboxymethyl-chitin
- ファルマシアレビュー : 13年を振り返って
- 磁気応答性を利用した胃内滞留性顆粒の調製と評価
- In Vitro pH-Dependent Drug Release from N^4-(4-Carboxybutyryl)-1-β-D-arabinofuranosylcytosine and Its Conjugate with Poly-L-lysine or Decylenediamine-dextran T70
- Novel Preparation of Decylenediamine-dextran T70 and Inhibitory Activity toward Dihydrofolate Reductase of Decylenediamine-dextran T70-Methotrexate Conjugate(Pharmaceutical)
- Preparation of Dextran T70-Methotrexate Conjugate and Dextran T70-Mycophenolic Acid Conjugate, and in Vitro Effect of Dextran T70-Methotrexate on Dihydrofolate Reductase
- Inclusion Complexes of Cinnarizine with β-Cyclodextrin in Aqueous Solution and in the Solid State
- In Vitro Dissolution Profile and in Vivo Absorption Study of Sustained-Release Tablets Containing Chlorpheniramine Maleate with Water-Insoluble Glucan
- Sustained-Release Dosage Forms Containing Chlorpheniramine Maleate with Water-Insoluble Glucan
- Studies on Powdered Preparations. XIX. Dissolution Kinetics of Benzoic Acid Derivatives
- Mathematical Optimization of Formulation of Indomethacin/Polyvinylpolypyrrolidone : Methyl Cellulose Solid Dispersions by the Sequential Unconstrained Minimization Technique
- Stabilization of Amorphous State of Indomethacin by Solid Dispersion in Polyvinylpolypyrrolidone
- Directly Compressed Tablets of Acetaminophen using Several Binding Agents
- 薬学と産業の未来への動的協調(21世紀へ向けての薬学の創造)
- 21世紀のDDS-開発研究のあり方を考える
- Adsorption of Benzoic Acid Derivatives by Carbon Black from Aqueous Solution and Related Phenomena
- Adsorption of Local Anesthetics from Aqueous Solution. Analysis of Factors Affecting the Nerve Blocking
- Particle Size Distribution Affects the Human Bioavailability of Phenytoin
- β-シクロデキストリン包接化合物に対する競合包接阻害物質としてのシンナリジンのIn vitro評価 : プロゲステロン膜透過速度に対する効果
- ラットにおけるアモキシシリン静脈内投与後の線形性
- HPCハイドロゲルを利用したアモキシシリン胃内浮遊徐放錠の問題点と簡便な製法についての検討
- H. ピロリ除菌を目的としたアモキシシリン胃内浮遊徐放錠の調製
- アモキシシリン胃内浮遊徐放錠の調製と評価
- Intestinal Absorption of Tocopherol in Beagle Dog and Effect of Dosage Form(Pharmaceutical,Chemical)
- A New Method of Dissolution Testing for Oily Drug Preparations Using an Improved Apparatus
- A New Method for Dissolution Testing of Vitamin E Preparations in Test Medium Containing Sodium Glycochenodeoxycholate
- Enhancement of the Bioavailability of Cinnarizine from Its β-Cyclodextrin Complex on Oral Administration with L-Isoleucine as a Competing Agent
- Evaluation of Bioavailability upon Oral Administration of Cinnarizine-β-Cyclodextrin Inclusion Complex to Beagle Dogs
- Effect of β-Cyclodextrin on the Degradation Rate of Cinnarizine in Aqueous Solution
- Kinetics of Degradation of Cinnarizine in Aqueous Solution
- Dissolution and Bioavailability of Phenytoin in Phenytoin-Polyvinylpyrrolidone-Sodium Deoxycholate Coprecipitate
- Particle Size Dependency of Dissolution Rate and Human Bioavailability of Phenytoin in Powders and Phenytoin-Polyethylene Glycol Solid Dispersions
- Sustained-Release Formulation of Buformin Hydrochloride
- Model Barrier Affecting Drug Transport
- Disintegration of the Aspirin Tablets containing Potato Starch and Microcrystalline Cellulose in Various Concentrations
- Effect of β-Cyclodextrin on the Degradation Rate of Amoxicillin in Acidic Solution
- 薬学と薬剤師と社会 : 哲学のある基礎学と実学
- Intranasal Administration of Human Fibroblast Interferon in Mice, Rats, Rabbits and Dogs
- Effect of Absorption Promoters in Intranasal Administration of Human Fibroblast Interferon as a Powder Dosage Form in Rabbits
- Enzyme Immunoassay of Human Fibroblast Interferon after Intranasal Administration with Several Excipients in Rabbits
- Dissolution Kinetics of Barbital Polymorphs
- Physico-chemical Approach to Biopharmaceutical Phenomena. I. Adsorption of Tryptophan from Aqueous Solution
- Dissolution Kinetics of Polyvinylpyrrolidone of Various Molecular Weights
- Dissolution Kinetics of Polyvinylpyrrolidone
- Rheological Studies on a Suspension of Water-Insoluble Glucan Produced by Streptococcus mutans(Pharmaceutical,Chemical)
- ファルマシア25年
- Adsorption of Phenothiazines from Aqueous Solution. Approach to Understanding of Membrane Action
- Dissolution of Thioridazine Hydrochloride from the Coprecipitate with Pectin
- Effect of β-Cyclodextrin on Sleeping Time Induced by Barbituric Acid Derivatives in Mice
- Specificity of Esterases and Structures of Prodrug Esters. III. Activity of Rat Tissue Homogenates, Rat Plasma and Porcine Liver Esterase for the Hydrolysis of 3', 5'-Bis-dicarboxylic Acid Hemiesters of 5-Fluoro-2'-deoxyuridine
- Specificity of Esterases and Structure of Prodrug Esters. II. Hydrolytic Regeneration Behavior of 5-Fluoro-2'-deoxyuridine (FUdR) from 3', 5'-Diesters of FUdR with Rat Tissue Homogenates and Plasma in Relation to Their Antitumor Activity
- Activity of Esterase in the Hydrolysis of 3', 5'-Diesters of 5-Fluoro-2'-deoxyuridine in Relation to the Structure of the Diester Prodrugs
- Optimum Formulation of Griseofulvin/Hydroxypropyl Cellulose Solid Dispersions with Desirable Dissolution Properties
- Factors Affecting the Dissolution of Griseofulvin Dispersed in Various Water-Soluble Polymers
- Dissolution Behavior of Chlorpropamide Polymorphs
- Highly Viscous Gel Ointment Containing Carbopol for Application to the Oral Mucosa
- Computer Optimization of Formulation of Flufenamic Acid/Polyvinylpolypyrrolidone/Methyl Cellulose Solid Dispersions
- Enhancement of Dissolution Properties of Prednisolone from Ground Mixtures with Chitin or Chitosan
- Dissolution Properties and Bioavailability of Phenytoin from Ground Mixtures with Chitin or Chitosan
- Dissolution of Diethazine Hydrochloride from the Coprecipitate with Pectin
- Development of a Tablet Excipient from Bagasse(Pharmaceutical)
- Kinetic Approach to Determine the Generation Rate of Available Surface Area during the Dissolution Process
- Effect of Compression Pressure and Formulation on the Available Surface Area of Flufenamic Acid in Tablets
- Influence of Wetting Factors on the Dissolution Behavior of Flufenamic Acid
- 医薬の薬効発現速度調節技術
- 薬物送達システム(DDS)の現状と展望
- 新薬開発への薬剤学的アプロ-チ
- 薬物送達システム(DDS) (化学のひろがり--異分野との接点を探る)
- Factors Affecting the Bioadhesive Property of Tablets Consisting of Hydroxypropyl Cellulose and Carboxyvinyl Polymer
- ヤシ油/アラビアゴム水溶液-界面膜粘弾性
- Complexation of Several Drugs with Water-Soluble Cyclodextrin Polymer(Pharmaceutical)
- Disintegration and Dissolution Characteristics of Compressed Tablets Consisting of Hydroxypropyl Cellulose and Carboxyvinyl Polymer
- 創剤-薬学における"Change"
- 薬師さま・永井家・父と私
- 新薬の研究と開発に関する国際シンポジウム
- 認識させるのは"人類の薬学"か"日本の薬学出身者の薬学"か(高校生への薬学紹介)
- 放出制御型薬物送達システム
- 日本薬学会功労賞紹介 斉藤太郎氏
- オクテット
- Computer Optimization of the Formulation of Acrylic Plaster
- 「医薬品の社会性」を薬学教育の中に取り入れることの是非が何故パネルのテーマになるのだろう(「医薬品の社会性」を薬学教育の中に取り入れることの是非)
- ビルマ国製薬研究開発センタープロジェクトに参加して
- 粘膜付着性製剤の開発
- Ointment-type Oral Mucosal Dosage Form of Carbopol containing Prednisolone for Treatment of Aphtha