Enzyme Immunoassay of Human Fibroblast Interferon after Intranasal Administration with Several Excipients in Rabbits
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概要
- 論文の詳細を見る
Human interferon-β (HuIFN-β) titer after intransal administration was determined by enzyme immunoassay (EIA), substituting for bioassay. The intranasal absorption was linearly related to HuIFN-β dose. Compared with intravenous administration, the mean bioavailability of intranasal HuIFN-β was 3%. The effects of several excipients, human serum albumin (HSA), polyethylene glycol, diethylaminoethyl-dextran, carboxy polymethylene, α-cyclodextrin and cholesteryl stearate, on the absorption of HuIFN-β were examined with the powder dosage form. Among these excipients, HSA and α-cyclodextrin gave the highest HuIFN-β concentrations in plasma. The area under the plasma concentration-time curve (AUC) decreased as the molecular weight of excipients was increased.
- 公益社団法人日本薬学会の論文
- 1988-08-25
著者
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井川 猛
Faculty Of Pharmaceutical Sciences Hoshi University
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永井 恒司
星薬科大学 薬剤
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町田 良治
Faculty of Pharmaceutical Sciences, Hoshi University
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永井 恒司
Faculty of Pharmaceutical Sciences, Hoshi University
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米谷 芳枝
星薬科大学
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米谷 芳枝
Faculty of Pharmaceutical Sciences, Hoshi University
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