Dissolution Behavior of Chlorpropamide Polymorphs

概要

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The dissolution profiles of chlorpropamide (CPM) polymorphs, especially the metastable form II reported by Al-Saieq et al., were investigated kinetically in detail by a dispersed amount method and a stationary disk method in comparison with those of the stable form. Form II showed a dissolution phenomenon involving simultaneous phase change from metastable form to stable form during dissolution. The saturated concentrations of metastable form II and stable form A, C_<sm> and C_<so>, the rate constant of the crystallization process K_r and the dissolution rate constant, K_1,were calculated by the stationary disk method. By analyzing the values of C_<sm> and C_<so> obtained at various temperatures, the transition temperature and heat of transition were determined. Further, the activation energies of crystallization and the dissolution process were also determined by Arrhenius plots of K_r and K_1 obtained at various temperatures.
公益社団法人日本薬学会の論文
1984-01-25