Nuclear Magnetic Resonance (NMR) Spectroscopy of Inclusion Compounds of Tolbutamide and Chlorpropamide with β-Cyclodextrin in Aqueous Solution
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概要
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A structural study of the inclusion compounds of tolbutamide and chlorpropamide with β-cyclodextrin in aqueous solution was attempted by means of proton nuclear magnetic resonance (^1H-NMR) and carbon-13 nuclear magnetic resonance (^<13>C-NMR) experiments. The changes in chemical shift (^1H, ^<13>C) and in relaxation times (^1H-T_1p, ^<13>C-T_1) suggested that the drug phenyl moiety was included in the cavity of β-CD mainly by hydrophobic interaction, and that the primary hydroxy side of β-CD was tightly associated with each drug. The binding mechanism and binding sites between the drug molecules and β-CD are discussed in detail.
- 公益社団法人日本薬学会の論文
- 1980-05-25
著者
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上田 晴久
星薬科大学
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永井 恒司
Hoshi Institute of Pharmaceutical Sciences
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上田 晴久
Hoshi Institute of Pharmaceutical Sciences
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