Permeation of Phenothiazines through Cellulose Membrane
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概要
- 論文の詳細を見る
The permeation of phenothiazines through cellulose membrane was investigated as a successive study of the adsorption from aqueous solution reported in a previous paper. The permeability decreased with the increase in molecular weight of phenothiazines. The activation energy of permeation was close to those of diffusion of usual organic medicinals in water. Any remarkable effect of pH on the permeation was not observed in the present conditions. It was demonstrated from these results that the permeation of phenothiazines through cellulose membrane proceeds on the basis of a diffusion through pore. In comparison with the diffusion constant of levomepromazine maleate in aqueous solution evaluated from the dissolution rate by the rotating disk method, the interaction coefficient of the diffusion through cellulose membrane was given as 0.453.
- 公益社団法人日本薬学会の論文
- 1971-04-25
著者
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南部 直樹
Faculty Of Pharmaceutical Sciences Hoshi University
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永井 恒司
Faculty of Pharmaceutical Sciences, Hoshi University
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野上 寿
Faculty of Pharmaceutical Sciences, University of Tokyo
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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