In Vitro Dissolution Profile and in Vivo Absorption Study of Sustained-Release Tablets Containing Chlorpheniramine Maleate with Water-Insoluble Glucan
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概要
- 論文の詳細を見る
In vitro dissolution profiles and in vivo absorption of chlorpheniramine maleate (CPM) from sustained-release tablets prepared with water-insoluble glucan produced by Streptococcus mutans were studied. Glucan alone or a conbination of glucan with lactose was used as a vehicle, and the tablets were made by direct compression method. The release rate of CPM increased with decreasing concentraion of glucan. The tablet containing 10mg of CPM and 190mg of glucan released CPM over 8h. Plasma levels of CPM following oral administration of the sustained-release tablets were low but were well sustained as compared with the result for the immediate-release tablet.
- 社団法人日本薬学会の論文
- 1984-09-25
著者
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松本 久美子
Faculty Of Pharmaceutical Sciences Kumamoto University
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林 信一
The Research And Development Division Of Rohto Pharmaceutical Co. Ltd.
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南部 直樹
Faculty Of Pharmaceutical Sciences Hoshi University
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永井 恒司
星薬科大学 薬剤
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永井 恒司
Faculty of Pharmaceutical Sciences, Hoshi University
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吉田 昭義
The Research Laboratories Of Rohto Pharmaceutical Co. Ltd.
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吉田 昭義
The Application And Development Division Of Rohto Pharmaceutical Co. Ltd.
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桝本 健
The Research and Development Department of Rohto Pharmaceutical Co., Ltd.
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松本 久美子
The Research and Development Department of Rohto Pharmaceutical Co., Ltd.
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桝本 健
ロート製薬
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