Equilibrium Studies of 5-Substituted 4-Hydroxy-2-methylpyrimidines. VI. Ethereal Solvents Effect on the Lactim-Lactam Tautomerism
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概要
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The lactim form, I, one of the tautomers of 5-carbethoxy-4-hydroxy-2-methylpyrimidine (1), in n-hexane was changed into the lactam form, IIb (4(3H)-pyrimidone) on addition of the ethereal solvents (ethyl ether, n-propyl ether, isopropyl ether, n-butyl ether and p-dioxane). The lactam form, IIb, increased with increasing the concentration of the etheriin n-hexane. The following association equilibria were examined. [chemical formula] The over-all association constant which was defined as K_0 (K_0=([I]+[IIb])[S]/[I']+[IIb']) was estimated. The K_0 values increased in that order : p-dioxane <isopropyl ether <ethyl ether <n-propyl ether <n-butyl ether.
- 社団法人日本薬学会の論文
- 1978-05-25
著者
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松本 久美子
Faculty Of Pharmaceutical Sciences Kumamoto University
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北川 隆康
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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北川 隆康
Shionogi Research Laboratories Shionogi & Co. Ltd.
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松本 久美子
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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平井 瑛三
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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北川 隆康
塩野義製薬(株)研究所
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平井 瑛三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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