Colorimetric Determination of 1-(2-o-Chlorobenzoyl-4-chlorophenyl)-5-glycylaminomethyl-3-dimethylaminocarbonyl-1H-1,2,4-triazole Hydrochloride Dihydrate with 3,5-Dibromosalicylaldehyde
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概要
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A colorimetric assay method was established for 1-(2-o-chlorobenzoyl-4-chlorophenyl)-5-glycylaminomethyl-3-dimethylaminocarbonyl-1H-1,2,4-triazole hydrochloride dihydrate (1), a sleep inducer, based on the reaction of 1 with 3,5-dibromosalicylaldehyde (DBSA) to give a redcolored substance in the presence of piperidine. Our previously established method employing DBSA was also applicable to 1. Compound 1 was determined with good precision and specificity. The general applicability of the assay method to compounds containing a glycinamide group was also examined.
- 公益社団法人日本薬学会の論文
- 1984-02-25
著者
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北川 隆康
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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北川 隆康
Shionogi Research Laboratories Shionogi & Co. Ltd.
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平井 瑛三
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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北川 隆康
塩野義製薬(株)研究所
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池西 利喜夫
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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平井 瑛三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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池西 利喜夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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