Analytical Studies on Isoxazoles. IV. : Fluorometric Determination of Isouron

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概要

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• A fluorometric method for the determination of isouron (1) was established by modifying Dombrowski's method. Isouron was hydrolyzed to 3-amino-5-tert-butylisoxazole (2) followed by diazo coupling with 2,6-diaminopyridine (DAP), and the resulting azo derivative (3) was oxidized to a fluorescent triazole (4). A simple nitrosation method was developed in order to overcome the interference by the strongly fluorescent reagent DAP. The oxidation yield of 3 to 4 was improved by employing the neutral condition. A linear relationship between the fluorescence intensity and isouron concentration was obtained in the range of 0.1-0.4 μg/ml. Isouron could be determined with a coefficient of variation of 2-3% (ten determinations), overall recovery of 85-90%, and quantitation limit of 40 ng/ml.

• 公益社団法人日本薬学会の論文
• 1981-08-25

著者

• 北川 隆康

  Shionogi Research Laboratories, Shionogi & Co., Ltd.,

• 北川 隆康

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 平井 瑛三

  Shionogi Research Laboratory, Shionogi and Co., Ltd.

• 北川 隆康

  塩野義製薬(株)研究所

• 岩倉 久美子

  Shionogi Research Laboratories, Shionogi and Co., Ltd.

• 平井 瑛三

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 岩倉 久美子

  Shionogi Research Laboratories Shionogi And Co. Ltd.

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