Analytical Studies on Isoxazoles. II. A New Fluorimetric Determination of 5-Phenyl-3-isoxazolecarboxylic Acid and Its Application to the Determination of Perisoxal in Plasma
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概要
- 論文の詳細を見る
A novel fluorimetric method is described for the determination of 5-phenyl-3-isoxazolecarboxylic acid (PIA) by using 2-hydroxy-1-naphthalenecarbaldehyde (HNA) ; this method was utilized to provide a specific and sensitive assay procedure for perisoxal in plasma. The developed fluorophore was 3-benzoyl-5,6-benzocoumarin (BBC), obtained by Knoevenagel condensation of benzoylacetonitrile with HNA, followed by cyclization. Linear relationships between fluorescence intensity and concentration existed over the concentration range of 35-350 ng/ml of PIA and 70-700 ng/ml of perisoxal in plasma. This method is 70 times more sensitive than the colorimetric method reported previously.
- 公益社団法人日本薬学会の論文
- 1980-12-25
著者
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梅田 常二
Shionogi Research Laboratories Shionogi & Co. Ltd.
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平井 瑛三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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平井 瑛三
Shionogi Research Laboratories Shionogi And Co. Ltd.
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今西 裕子
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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今西 裕子
Shionogi Research Laboratory Shionogi And Co. Ltd.
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