3,5-ジブロムサリチルアルデヒドを用いる4-クロロ-2-(o-クロロベンゾイル)-N-メチル-N^α-グリシルグリシンアニリドの比色定量法
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概要
- 論文の詳細を見る
A colorimetric method for the determination of a new type minor tranquilizer, 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-glycylglycinanilide (1), was developed in order to estimate the quality of raw material. Compound 1 was heated in dimethyl sulfoxide with 3,5-dibromosalicylaldehyde in the presence of piperidine catalyst. The resulting red colored product had absorption maximum at 554 nm. The calibration curve was linear in the range of 0.5-2.0 mg/ml of standard solution of 1 with coefficient of variation less than 1%. Compound 1 was assayed without interference even in the presence of various impurities estimated from synthetic process.
- 公益社団法人日本薬学会の論文
- 1981-06-25
著者
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北川 隆康
Shionogi Research Laboratories Shionogi & Co. Ltd.
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北川 隆康
塩野義製薬(株)研究所
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平井 瑛三
塩野義製薬株式会社研究所
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平井 瑛三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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池西 利喜夫
塩野義製薬株式会社研究所
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池西 利喜夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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