Equilibrium Studies of 5-Substituted 4-Hydroxy-2-methylpyrimidines. III. Photometric Titration in n-Butanol

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概要

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• Photometric titration for 5-substituted 4-hydroxy-2-methylpyrimidine and its methyl derivatives was performed in n-BuOH. An equation for the titration was derived in consideration of ion pair formation in n-BuOH. [numerical formula] It was proved that Higuchi's Type II plot method was applicable only under a condition, K_<BHX>=K_<IHX>, from the analysis of the titration curves. The over-all dissociation constant of the pyrimidines (K^<n-BuOH>_<BH>=K^<O>_<HX>/K_BK_<BHX>=[H^+] [B]f_H/[BH^+] f_<BH>) was estimated from the slope of the titration curve. The basicities of the compounds in n-BuOH generally increased as compared with those in water (ΔpK=pK^<n-BuOH>_<BH>-pK_a=-0.1-2.3). The degrees of the increase differed largely among the compounds. Much larger increase of the basicity than the other compounds (ΔpK ; 2.1-2.3) was found for 5-substituted 1,2-dimethyl-4(1H)-pyrimidones.

• 公益社団法人日本薬学会の論文
• 1978-01-25

著者

• 北川 隆康

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 北川 隆康

  塩野義製薬(株)研究所

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